Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG14118MIP11263p; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (439 aa)    
Predicted Functional Partners:
Tengl3
Testis EndoG-Like 3; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation.
      
 0.655
CG9593
Fibrinogen C-terminal domain-containing protein; Transmembrane receptor protein tyrosine kinase activator activity. It is involved in the biological process described with: negative regulation of apoptotic process.
    
 
 0.624
CG30428
Uncharacterized protein, isoform A; It is involved in the biological process described with: apoptotic process.
    
 
 0.608
CG4364
Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.
   
 
 0.554
Achl
Achilles, isoform A; Achilles (Achl) is a clock-controlled gene that is expressed in a rhythmic manner in the brain. It regulates wing development and expression of antimicrobial peptides.
   
  
 0.520
Orct
Organic cation transporter protein; Probably transports organic cations.
    
 
 0.518
Drep3
DNA fragmentation factor-related protein 3 (Drep3) encodes a CIDE domain containing protein that can interact with the proteins encoded by Drep2 and Drep4 via CIDE-CIDE interaction.
      
 0.516
CG14805
FI20216p1; It is involved in the biological process described with: regulation of DNA-dependent DNA replication initiation; rRNA processing.
   
 
 0.487
NijA
Ninjurin A (NijA) encodes a transmembrane protein of the conserved Ninjurin family. It is upregulated in response to injury and infection, suggesting a role in immune or stress responses. When overexpressed the product of NijA causes cell death.
      
 0.479
Cdk5alpha
Cdk5 activator-like protein (Cdk5alpha) encodes the sole, essential stimulatory subunit for the kinase encoded by Cdk5. The Cdk5/Cdk5alpha complex is active in post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.
      
 0.467
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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