STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Zmynd10Zinc finger MYND domain-containing protein 10 homolog; Plays a role in axonemal structure organization and motility. May be involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility; Belongs to the ZMYND10 family. (451 aa)    
Predicted Functional Partners:
HEATR2
Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.
      
 0.939
Dnai2
Dynein, axonemal, intermediate chain 2 (Dnai2) encodes a subunit of the axonemal dynein complex. It is involved in the perception of sound and sperm competititon.
   
  
 0.934
Spag1
Spag1 axonemal dynein assembly factor; Heat shock protein binding. It is involved in the biological process described with: protein targeting to mitochondrion.
   
  
 0.933
Dnali1
Putative inner dynein arm light chain, axonemal; May play a dynamic role in flagellar motility.
   
  
 0.915
Rsph1
AT19426p; It is involved in the biological process described with: axoneme assembly.
   
 
 0.909
unc79
Uncoordinated 79 (unc79) encodes a protein involved in circadian locomotor rhythms.
   
 
 0.907
tilB
Protein tilB; Touch insensitive larva B (tilB) encodes a protein required for the assembly and/or transport to the cilium of axonemal dynein arms. tilB depletion results in deafness and male sterility because it specifically affects chordotonal neurons and spermatids, the only fly motile cilia cells. It interacts with the product of Zmynd10, which has a similar distribution and mutant phenotype.
    
 
 0.888
Rsph4a
GH13165p; It is involved in the biological process described with: cilium movement; axoneme assembly.
   
  
 0.887
CG17669
Dynein assembly factor 3, axonemal homolog; Required for the assembly of axonemal inner and outer dynein arms; Belongs to the DNAAF3 family.
   
  
 0.849
gudu
Armadillo repeat-containing protein gudu; Important for spermatogenesis where it may have a role in sperm individualization.
   
  
 0.827
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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