STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KlcKinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (508 aa)    
Predicted Functional Partners:
Khc
Kinesin heavy chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily
   
 0.999
syd
JNK-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK-signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Syd is required for efficient kinesin-I mediated axonal transport
   
 
 0.993
unc-104
Kinesin-like protein unc-104; Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily
    
 0.977
Aplip1
JNK-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity)
   
 
 0.970
Khc-73
Kinesin heavy chain 73, isoform A; ATP binding; microtubule binding; microtubule motor activity; protein homodimerization activity. It is involved in the biological process described with: establishment of spindle orientation; regulation of synapse structure and activity; microtubule-based movement; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family
   
 0.957
Klp68D
Kinesin-like protein at 68D (Klp68D) is the kinesin-2beta motor subunit of the heterotrimeric kinesin-2. Klp68D associates with Klp64D and Kap3. Klp68D plays an essential role in the sensory cilia assembly, microtubule organization in dendrites, and axonal transport
    
 0.951
Kap3
Kinesin associated protein 3 (Kap3) is the non-motor accessory subunit of the heterotrimeric kinesin-2. Kap3 associates to the coiled-coil stalk domain of Klp68D andKlp64D. Kap3 plays an essential role in sensory cilia assembly and axonal transport
   
 
 0.950
Klp64D
Kinesin-like protein at 64D (Klp64D) is the kinesin-2alpha motor subunit of the heterotrimeric kinesin-2. Klp64D associates with Klp68D and Kap3. Klp64D plays an essential role in sensory cilia assembly and axonal transport; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family
   
 0.948
unc-119
Protein unc-119 homolog; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization
    
 0.942
Klp61F
Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...]
   
 0.930
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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