Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG4069LD47970p. (509 aa)    
Predicted Functional Partners:
B52
Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin.
    
   0.814
l(1)G0004
RNA-binding protein pno1; RNA binding.
   
   0.745
GCC88
GRIP and coiled-coil domain containing 88 kDa; ADP-ribosylation factor binding; Rab GTPase binding. It is involved in the biological process described with: Golgi vesicle transport.
   
   0.745
CG9776
Zinc finger matrin-type protein CG9776; It is involved in the biological process described with: positive regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated.
    
   0.707
CG7839
IP14658p; It is involved in the biological process described with: ribosome biogenesis.
   
    0.688
nesd
Protein nessun dorma; Required during male meiosis for completion of spermatocyte cytokinesis and possibly also required in female germline cells. Also involved in ring canal formation in male and female germline cells. Not essential for cleavage furrow ingression but is required for contractile ring stability and the attachment of the furrowing membrane to the actomyosin ring in late telophase. Displays high binding affinity for beta-galactosides.
      
 0.683
CG7246
RE67794p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
   
    0.638
pAbp
Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...]
    
 
 0.612
CG5721
Armadillo repeat-containing protein 6 homolog; It is involved in the biological process described with: hematopoietic progenitor cell differentiation; Belongs to the ARMC6 family.
      
 0.604
CROT
Carnitine O-octanoyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation.
    
   0.600
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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