node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
eIF1 | eIF1A | FBpp0072908 | FBpp0310418 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition. | 0.999 |
eIF1 | eIF2Balpha | FBpp0072908 | FBpp0084874 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 2B subunit alpha (eIF2Balpha) encodes a regulatory subunit of the eIF2B heteropentamer; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.578 |
eIF1 | eIF2Bdelta | FBpp0072908 | FBpp0071923 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 2B subunit delta, isoform A; Translation initiation factor activity. It is involved in the biological process described with: translational initiation; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.811 |
eIF1 | eIF2Bepsilon | FBpp0072908 | FBpp0089217 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 2B subunit epsilon (eIF2Bepsilon) encodes a guanyl-nucleotide exchange factor. | 0.621 |
eIF1 | eIF2Bgamma | FBpp0072908 | FBpp0086469 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 2B subunit gamma; Translation initiation factor activity; nucleotidyltransferase activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: translational initiation; cellular response to hypoxia; cytoplasmic translational initiation. | 0.445 |
eIF1 | eIF2alpha | FBpp0072908 | FBpp0309768 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha) encodes one of three subunits of the eIF-2 complex required for the initiation of translation. eIF2alpha is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles. | 0.995 |
eIF1 | eIF2beta | FBpp0072908 | FBpp0075700 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region; Belongs to the eIF-2-beta/eIF-5 family. | 0.998 |
eIF1 | eIF2gamma | FBpp0072908 | FBpp0307983 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 2 subunit 3; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cataly [...] | 0.997 |
eIF1 | eIF3c | FBpp0072908 | FBpp0309235 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. | 0.999 |
eIF1 | eIF5 | FBpp0072908 | FBpp0089136 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity). | 0.999 |
eIF1A | eIF1 | FBpp0310418 | FBpp0072908 | Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition. | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | 0.999 |
eIF1A | eIF2Bdelta | FBpp0310418 | FBpp0071923 | Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition. | Eukaryotic translation initiation factor 2B subunit delta, isoform A; Translation initiation factor activity. It is involved in the biological process described with: translational initiation; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.479 |
eIF1A | eIF2alpha | FBpp0310418 | FBpp0309768 | Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition. | Eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha) encodes one of three subunits of the eIF-2 complex required for the initiation of translation. eIF2alpha is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles. | 0.997 |
eIF1A | eIF2beta | FBpp0310418 | FBpp0075700 | Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition. | Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region; Belongs to the eIF-2-beta/eIF-5 family. | 0.998 |
eIF1A | eIF2gamma | FBpp0310418 | FBpp0307983 | Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition. | Eukaryotic translation initiation factor 2 subunit 3; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cataly [...] | 0.993 |
eIF1A | eIF3c | FBpp0310418 | FBpp0309235 | Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition. | Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. | 0.988 |
eIF1A | eIF5 | FBpp0310418 | FBpp0089136 | Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition. | Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity). | 0.987 |
eIF2Balpha | eIF1 | FBpp0084874 | FBpp0072908 | Eukaryotic translation initiation factor 2B subunit alpha (eIF2Balpha) encodes a regulatory subunit of the eIF2B heteropentamer; Belongs to the eIF-2B alpha/beta/delta subunits family. | Eukaryotic translation initiation factor eIF1; Probably involved in translation. | 0.578 |
eIF2Balpha | eIF2Bdelta | FBpp0084874 | FBpp0071923 | Eukaryotic translation initiation factor 2B subunit alpha (eIF2Balpha) encodes a regulatory subunit of the eIF2B heteropentamer; Belongs to the eIF-2B alpha/beta/delta subunits family. | Eukaryotic translation initiation factor 2B subunit delta, isoform A; Translation initiation factor activity. It is involved in the biological process described with: translational initiation; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.999 |
eIF2Balpha | eIF2Bepsilon | FBpp0084874 | FBpp0089217 | Eukaryotic translation initiation factor 2B subunit alpha (eIF2Balpha) encodes a regulatory subunit of the eIF2B heteropentamer; Belongs to the eIF-2B alpha/beta/delta subunits family. | Eukaryotic translation initiation factor 2B subunit epsilon (eIF2Bepsilon) encodes a guanyl-nucleotide exchange factor. | 0.999 |