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RhoGAP68F protein (fruit fly) - STRING interaction network
"RhoGAP68F" - Rho GTPase activating protein at 68F in Drosophila melanogaster
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RhoGAP68FRho GTPase activating protein at 68F (RhoGAP68F) is a GTPase activating protein acting upon small Rho-family GTPases involved in epithelial morphogenesis. It localizes to Rab4 recycling endosomes, forms a complex with the Rab4 protein and modulates the transport of Rab4 recycling endosomes back to the cell surface (476 aa)    
Predicted Functional Partners:
Cdc42
Cdc42 is a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily (191 aa)
     
  0.991
Rho1
Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization- required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During embryogenesis, acts upstream of wash to regulate the developmental migration of tail hemocytes anteriorly along the ventral midline. May have a role in eye development (192 aa)
     
  0.972
Rac1
Ras-related protein Rac1; Involved in axon outgrowth and myoblast fusion. Plays a role in regulating dorsal closure during embryogenesis. Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram- positive S.aureus by hemocytes; Belongs to the small GTPase superfamily. Rho family (192 aa)
       
  0.950
RhoU
RhoU, isoform B; GTPase activity; GTP binding. It is involved in the biological process described with- small GTPase mediated signal transduction; Belongs to the small GTPase superfamily. Rho family (582 aa)
       
  0.944
Rac2
Ras-related protein Rac2; Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes (192 aa)
       
  0.940
RhoBTB
Rho-related BTB domain containing, isoform B; GTPase activity; GTP binding. It is involved in the biological process described with- melanotic encapsulation of foreign target; small GTPase mediated signal transduction (745 aa)
     
  0.938
RhoL
Ras-like GTP-binding protein RhoL; Essential for the maturation of hemocytes (214 aa)
       
  0.920
Miro
Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs) (673 aa)
     
    0.907
Rab4
Rab4, isoform A; GTPase activity; GTP binding. It is involved in the biological process described with- vesicle-mediated transport; Rab protein signal transduction; protein transport; endocytosis (213 aa)
     
 
  0.740
CG7083
annotation not available (438 aa)
     
   
  0.715
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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