STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCID2PCI domain-containing protein 2 homolog; Required for mRNA export together with Moe. Associates with translationally active polysomes. (395 aa)    
Predicted Functional Partners:
xmas
Protein xmas-2; Xmas (xmas) encodes encodes a hydrophilic protein that is involved in spermatogenesis, oogenesis and embryogenesis.
   
 0.998
e(y)2
Enhancer of yellow 2 transcription factor; Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in t [...]
   
 0.997
Sem1
Probable 26S proteasome complex subunit sem1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis.
    
 
 0.979
CG6700
Uncharacterized protein, isoform A.
   
 
 0.959
CG3437
Uncharacterized protein; It is involved in the biological process described with: centrosome duplication; spindle assembly.
   
 
 0.922
CG17493
Uncharacterized protein, isoform B; Calcium ion binding. It is involved in the biological process described with: mitotic cell cycle; centriole replication.
   
 
 0.897
sbr
Nuclear RNA export factor 1; Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm.
    
 
 0.850
Rae1
Rae1 (Rae1) encodes a nucleoporin member of the WD40-repeat beta propeller protein super family. Biological roles of the pleiotropic Rae1 gene product include poly(A)+ mRNA export, cell cycle regulation, male meiosis control and male germ cell post-meiotic differentiation.
   
  
 0.823
CG42750
Dipeptidase; Beta-lactamase activity; dipeptidase activity; dipeptidyl-peptidase activity; metalloexopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
    
 
 0.816
CG12782
WD_REPEATS_REGION domain-containing protein; Ubiquitin binding; RNA binding. It is involved in the biological process described with: RNA export from nucleus; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; mRNA export from nucleus.
   
  
 0.774
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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