Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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CG6083FI19917p1; Oxidoreductase activity; alcohol dehydrogenase (NADP+) activity; alditol:NADP+ 1-oxidoreductase activity. It is involved in the biological process described with: oxidation-reduction process; mushroom body development. (322 aa)    
Predicted Functional Partners:
Sodh-2
Sorbitol dehydrogenase-2; L-iditol 2-dehydrogenase activity; zinc ion binding. It is involved in the biological process described with: oxidation-reduction process; sorbitol catabolic process.
  
 0.948
Sodh-1
Sorbitol dehydrogenase 1, isoform A; Zinc ion binding; L-iditol 2-dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process; sorbitol catabolic process.
  
 0.945
Dhfr
Dihydrofolate reductase (Dhfr) encodes an NADPH-dependent enzyme used to convert folic acid and dihydrofolate to tetrahydrofolate, which is used as a cofactor for the biosynthesis of purines, thymidylate, and several amino acids. Dhfr product contributes to cell proliferation and cell growth.
  
 
 0.915
Dhpr
NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process.
  
 0.914
se
Pyrimidodiazepine synthase; Mediates the conversion of 2-amino-4-oxo-6-pyruvoyl-5,6,7,8- tetrahydropteridine (6-PTP; also named 6-pyruvoyltetrahydropterin) to 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4- one (pyrimidodiazepine or PDA), a key intermediate in red eye pigment drosopterin biosynthesis.
    
 0.904
Gal
Beta galactosidase (Gal) encodes a putative digestive enzyme that hydrolyses beta-galactosides into monosaccharides. Gal is highly expressed and enriched in the midgut, an organ involved in digestion; Belongs to the glycosyl hydrolase 35 family.
    
 0.903
Ect3
Beta-galactosidase activity. It is involved in the biological process described with: carbohydrate metabolic process.
    
 0.903
Trh
Tryptophan hydroxylase (Trh) encodes an enzyme that functions as the first and rate-limiting step in the synthesis of serotonin.
   
 
  0.902
Hn
Henna (Hn) encodes a tryptophan phenylalanine hydroxylase. It is a dual function enzyme: it hydroxylates both phenylalanine to generate tyrosine, as well as tryptophan to generate the precursor for peripheral (non-neuronal) serotonin. It is also involved in pteridine synthesis.
   
 
  0.902
CG7322
RH57257p; Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; carbonyl reductase (NADPH) activity; L-xylulose reductase (NADP+) activity. It is involved in the biological process described with: xylulose metabolic process; glucose metabolic process.
     
 0.902
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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