Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CG12362RBR-type E3 ubiquitin transferase; Ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; protein polyubiquitination. (511 aa)    
Predicted Functional Partners:
Cul3
Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family.
   
 
 0.919
Ubc10
Ubiquitin-conjugating enzyme E2-18 kDa; Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins. Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the [...]
    
 
 0.847
CG2267
GH11073p.
   
    0.808
CG6304
GH09088p.
   
    0.808
CG2955
GH14206p; Microtubule plus-end binding; microtubule binding. It is involved in the biological process described with: spindle assembly; regulation of microtubule polymerization or depolymerization; protein localization to microtubule plus-end; protein localization to microtubule.
   
    0.803
CG6380
AT25465p; Protein phosphatase inhibitor activity. It is involved in the biological process described with: regulation of phosphoprotein phosphatase activity; regulation of signal transduction.
   
    0.786
CG4712
FI19336p1.
   
    0.784
bb8
Big bubble 8 (bb8) encodes a glutamate dehydrogenase involved in the development of the spermatid mitochondria; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
    0.782
CG17344
Uncharacterized protein.
   
    0.779
CG5614
FI08029p; It is involved in the biological process described with: cilium assembly.
   
    0.776
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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