Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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PrpsUncharacterized protein, isoform B; Magnesium ion binding; ATP binding; ribose phosphate diphosphokinase activity. It is involved in the biological process described with: ribonucleoside monophosphate biosynthetic process; purine nucleotide biosynthetic process; nucleoside metabolic process; nucleotide biosynthetic process; 5-phosphoribose 1-diphosphate biosynthetic process. (388 aa)    
Predicted Functional Partners:
CG2246
GH23275p; Magnesium ion binding; ribose phosphate diphosphokinase activity. It is involved in the biological process described with: nucleotide biosynthetic process; 5-phosphoribose 1-diphosphate biosynthetic process; nucleoside metabolic process; purine nucleotide biosynthetic process.
  
 
0.997
Rpi
Ribose-5-phosphate isomerase activity. It is involved in the biological process described with: age-dependent response to reactive oxygen species; D-ribose metabolic process; pentose-phosphate shunt, non-oxidative branch.
  
 
 0.973
Prat2
Amidophosphoribosyltransferase; Phosphoribosylamidotransferase 2 (Prat2) encodes a type-2 glutamine amidotransferase that is essential in the pathway for de novo synthesis of inosine monophosphate (IMP). IMP is the precursor for purine nucleotides that are required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 0.971
CG8036
LP07963p; Transketolase activity; thiamine pyrophosphate binding. It is involved in the biological process described with: regulation of chromatin silencing.
   
 
 0.958
CG5103
FI06132p; Transketolase activity; thiamine pyrophosphate binding.
   
 
 0.955
CG13369
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
   
 0.950
CG17010
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
   
 0.950
r-l
Orotidine 5'-phosphate decarboxylase; Rudimentary-like (r-l) encodes an enzyme involved in the novo pyrimidine biosynthesis; In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.950
Pgm2b
Phosphoglucomutase 2b; Intramolecular transferase activity, phosphotransferases. It is involved in the biological process described with: carbohydrate metabolic process.
  
 0.948
Pgm2a
Phosphoglucomutase 2a; Magnesium ion binding; intramolecular transferase activity, phosphotransferases. It is involved in the biological process described with: carbohydrate metabolic process.
  
 0.948
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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