Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CG3408RE10106p. (331 aa)    
Predicted Functional Partners:
Tudor-SN
Staphylococcal nuclease domain-containing protein 1; Endonuclease which shows activity towards both DNA and RNA substrates. Has a role in translation regulation throught its association with the with the RNA- induced silencing complex (RISC). Plays a role in spermatogenesis probably by negatively regulating piwi expression in the germline. Together with piwi, might be involved in transposon repression in the germline.
   
 
 0.932
stau
Maternal effect protein staufen; RNA-binding protein which forms ribonucleoprotein complexes (RNPs) that play critical roles in the localization, translational repression and turnover of RNAs during embryogenesis, neurotransmission and neurogenesis. In the oocyte, essential for the localization of both the osk/oskar mRNA to the posterior pole and bcd/bicoid RNA to the anterior pole, and is therefore required for the correct anterior- posterior patterning of the developing embryo. Association with osk or bcd at their respective poles, appears to promote the formation and stabilization o [...]
    
   0.711
Sec63
Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation.
   
   0.659
CG8042
BcDNA.GH10229.
   
  
 0.657
yps
Ypsilon schachtel, isoform A; Nucleic acid binding; protein binding; mRNA binding. It is involved in the biological process described with: oogenesis; mRNA splicing, via spliceosome; regulation of gene expression.
    
   0.656
rump
Rumpelstiltskin, isoform A; Rumpelstiltskin (rump) encodes the Drosophila hnRNP M homolog. It binds to nos and osk mRNAs and plays a role in mRNA localization to the germ plasm by diffusion/entrapment during late stages of oogenesis. It also binds to exonic splicing enhancers on pre-mRNA targets, implicating it as a splicing factor.
    
 
 0.639
Rab14
Rab14, isoform B; Rab14 (Rab14) encodes a protein involved in phagocytosis, phagolysosome assembly and phagosome acidification.
    
 
 0.621
RabX6
RabX6, isoform B; GTPase activity; GTP binding. It is involved in the biological process described with: intracellular protein transport; Rab protein signal transduction; vesicle-mediated transport.
    
 
 0.621
CG1983
Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
      
 0.571
CG32022
AT11343p; It is involved in the biological process described with: oogenesis; tail-anchored membrane protein insertion into ER membrane.
      
 0.570
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.