STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TatAlpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (461 aa)    
Predicted Functional Partners:
HDAC6
Histone deacetylase 6, isoform G; Histone deacetylase 6 (HDAC6) encodes a cytosolic deacetylase that functions as a key modulator of proteostasis by mediating ubiquitin-proteasomal and lysosomal degradation of native and/or misfolded proteins.
      
 0.697
CG8321
LD43023p.
      
 0.626
CG42697
Uncharacterized protein.
      
 0.626
Sirt2
NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily.
      
 0.619
TTLL5
Tubulin tyrosine ligase-like 5, isoform A; Protein-glycine ligase activity; tubulin-glutamic acid ligase activity; ATP binding; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; C-terminal protein amino acid modification; protein polyglycylation; protein polyglutamylation.
   
  
 0.585
TTLL4B
Tubulin tyrosine ligase-like 4B, isoform B; ATP binding; protein-glycine ligase activity; tubulin-glutamic acid ligase activity; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation.
      
 0.536
TTLL1B
Tubulin tyrosine ligase-like 1B; Tubulin binding; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity. It is involved in the biological process described with: protein polyglutamylation; microtubule cytoskeleton organization; protein polyglycylation.
   
  
 0.516
TTLL1A
Tubulin tyrosine ligase-like 1A; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity; tubulin binding. It is involved in the biological process described with: microtubule cytoskeleton organization; protein polyglycylation; protein polyglutamylation.
   
  
 0.511
TTLL4A
Tubulin tyrosine ligase-like 4A, isoform D; ATP binding; tubulin-glutamic acid ligase activity; protein-glycine ligase activity; tubulin binding. It is involved in the biological process described with: protein polyglutamylation; microtubule cytoskeleton organization; protein polyglycylation; wound healing.
   
  
 0.511
betaTub56D
Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.
      
 0.481
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.