node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
4E-T | CG5800 | FBpp0088297 | FBpp0074227 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | 0.684 |
4E-T | Thor | FBpp0088297 | FBpp0077213 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | 4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. | 0.530 |
4E-T | cup | FBpp0088297 | FBpp0312102 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | Protein cup; Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos. Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation. Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G. This may contribute to translational repression but does not appear to be necessary for it to occur. Can promote translational repression independently of deadenylation and eIF4E1 binding. Required for correct localizat [...] | 0.523 |
4E-T | eIF4A | FBpp0088297 | FBpp0297911 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | Eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation. | 0.607 |
4E-T | eIF4B | FBpp0088297 | FBpp0112403 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | Eukaryotic translation initiation factor 4B (eIF4B) encodes a protein involved in cap-dependent translation, cell survival, and proliferation. | 0.489 |
4E-T | eIF4E1 | FBpp0088297 | FBpp0306017 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family. | 0.997 |
4E-T | eIF4G1 | FBpp0088297 | FBpp0111817 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | Eukaryotic translation initiation factor 4G1 (eIF4G1) encodes a protein that contributes to translation and spermatogenesis. | 0.836 |
4E-T | me31B | FBpp0088297 | FBpp0079565 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | ATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...] | 0.978 |
4E-T | pAbp | FBpp0088297 | FBpp0085919 | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...] | 0.540 |
CG5800 | 4E-T | FBpp0074227 | FBpp0088297 | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | 0.684 |
CG5800 | Thor | FBpp0074227 | FBpp0077213 | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | 4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. | 0.493 |
CG5800 | cup | FBpp0074227 | FBpp0312102 | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | Protein cup; Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos. Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation. Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G. This may contribute to translational repression but does not appear to be necessary for it to occur. Can promote translational repression independently of deadenylation and eIF4E1 binding. Required for correct localizat [...] | 0.454 |
CG5800 | eIF4A | FBpp0074227 | FBpp0297911 | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | Eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation. | 0.659 |
CG5800 | eIF4B | FBpp0074227 | FBpp0112403 | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | Eukaryotic translation initiation factor 4B (eIF4B) encodes a protein involved in cap-dependent translation, cell survival, and proliferation. | 0.544 |
CG5800 | eIF4E1 | FBpp0074227 | FBpp0306017 | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family. | 0.993 |
CG5800 | eIF4G1 | FBpp0074227 | FBpp0111817 | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | Eukaryotic translation initiation factor 4G1 (eIF4G1) encodes a protein that contributes to translation and spermatogenesis. | 0.977 |
CG5800 | pAbp | FBpp0074227 | FBpp0085919 | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...] | 0.875 |
Thor | 4E-T | FBpp0077213 | FBpp0088297 | 4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. | eIF4E-Transporter, isoform B; eIF4E-Transporter (4E-T) encodes a large protein that interacts with regulators of translation and mRNA stability, including CNOT1 and LSM14 as well as the products of me31B and eIF4E1. Levels of the 4E-T product are particularly high in germ cells and early development when translational control predominates in gene regulation. | 0.530 |
Thor | CG5800 | FBpp0077213 | FBpp0074227 | 4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. | ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: rRNA processing; larval somatic muscle development. | 0.493 |
Thor | eIF4A | FBpp0077213 | FBpp0297911 | 4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. | Eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation. | 0.919 |