Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG5026LD06050p; Phosphatidylinositol-3-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol dephosphorylation; negative regulation of autophagy. (620 aa)    
Predicted Functional Partners:
CG3530
GH09546p; Metal ion binding; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol dephosphorylation; mitotic cell cycle; regulation of autophagy.
  
0.998
CtsB1
Cathepsin B1 (CtsB1) encodes a papain-like cysteine proteinase involved in lysosomal protein degradation; Belongs to the peptidase C1 family.
   
  
 0.819
MsrA
Ecdysone-induced protein 28/29kD (Eip71CD) encodes a methionine-S-sulfoxide reductase involved in the response to oxidative stress. It contributes to determination of adult lifespan and neuron projection.
      
 0.728
CG8349
CMP/dCMP-type deaminase domain-containing protein; Cytidine deaminase activity; zinc ion binding. It is involved in the biological process described with: cytidine deamination.
    
   0.693
CG8360
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
    
   0.693
CG8353
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
    
   0.693
Ptp69D
Protein tyrosine phosphatase 69D (Ptp69D) encodes a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have embryonic motor axon guidance phenotypes. In particular, Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp69D physically and genetically interacts with the product of Dscam1 to regulate arborization of mechanosensory neurons; Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
   
  
 0.684
RIOK2
RIO kinase 2; Protein kinase activity; protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: positive regulation of glial cell proliferation; maturation of SSU-rRNA; protein phosphorylation.
   
  
 0.659
CG8485
Uncharacterized protein, isoform A; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation.
   
  
 0.659
RIOK1
Serine/threonine-protein kinase RIO1; ATP binding; protein kinase activity; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; positive regulation of glial cell proliferation; maturation of SSU-rRNA; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
   
  
 0.643
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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