Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DhprNADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process. (235 aa)    
Predicted Functional Partners:
Pcd
4-alpha-hydroxytetrahydrobiopterin dehydratase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process.
   
 
 0.989
CG12116
RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process.
   
 0.977
Sptr
Sepiapterin reductase (Sptr) encodes a sepiapterin reductase involved in the biosynthesis of tetrahydrobiopterin.
   
 0.973
Dhfr
Dihydrofolate reductase (Dhfr) encodes an NADPH-dependent enzyme used to convert folic acid and dihydrofolate to tetrahydrofolate, which is used as a cofactor for the biosynthesis of purines, thymidylate, and several amino acids. Dhfr product contributes to cell proliferation and cell growth.
   
 
 0.972
Hn
Henna (Hn) encodes a tryptophan phenylalanine hydroxylase. It is a dual function enzyme: it hydroxylates both phenylalanine to generate tyrosine, as well as tryptophan to generate the precursor for peripheral (non-neuronal) serotonin. It is also involved in pteridine synthesis.
  
 0.962
Trh
Tryptophan hydroxylase (Trh) encodes an enzyme that functions as the first and rate-limiting step in the synthesis of serotonin.
   
 0.952
ple
Pale (ple) encodes a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development.
  
 0.947
Akr1B
AT18092p; Indanol dehydrogenase activity; alcohol dehydrogenase (NADP+) activity; oxidoreductase activity; alditol:NADP+ 1-oxidoreductase activity. It is involved in the biological process described with: oxidation-reduction process.
  
 0.919
Pu
GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation.
  
 
 0.915
CG10863
BcDNA.GH10614; alditol:NADP+ 1-oxidoreductase activity; indanol dehydrogenase activity; oxidoreductase activity; alcohol dehydrogenase (NADP+) activity. It is involved in the biological process described with: oxidation-reduction process.
  
 0.914
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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