Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG5653Amino_oxidase domain-containing protein; Oxidoreductase activity; polyamine oxidase activity. It is involved in the biological process described with: oxidation-reduction process. (476 aa)    
Predicted Functional Partners:
CG1673
Branched-chain-amino-acid transaminase activity. It is involved in the biological process described with: valine biosynthetic process; branched-chain amino acid biosynthetic process; leucine biosynthetic process; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
      
 0.740
Ugt37A3
UDP-glycosyltransferase family 37 member A3; Transferase activity, transferring hexosyl groups; UDP-glycosyltransferase activity.
      
 0.654
Cyp309a1
Probable cytochrome P450 309a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
      
 0.651
Nmdmc
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; May play a role in spermatogenesis.
      
 0.599
CG42807
GH09427p.
      
 0.590
Arc1
Activity-regulated cytoskeleton associated protein 1; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles. Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation. Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction. May play a role in energy balance: required for regulation of body fat b [...]
      
 0.537
dhd
Thioredoxin-1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. Required for female meiosis and early embryonic development.
      
 0.472
CG32368
GEO12732p1.
      
 0.471
para
Sodium channel protein para; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
   
  
 0.464
SamDC
S-adenosylmethionine decarboxylase (SamDC) encodes a protein involved in defense response to Gram-negative bacterium; Belongs to the eukaryotic AdoMetDC family.
      
 0.462
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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