Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG13667NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family. (582 aa)    
Predicted Functional Partners:
CIAPIN1
Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]
   
 
 0.997
CG6523
LD40224p; Protein disulfide oxidoreductase activity; electron transfer activity. It is involved in the biological process described with: cellular iron ion homeostasis; cell redox homeostasis.
    
 
 0.917
Cyp6a8
Cytochrome P450 6a8; Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
 
  
 
 0.901
Cyp6a18
Probable cytochrome P450 6a18; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
 
  
 
 0.900
Cyp4s3
Probable cytochrome P450 4s3; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
 
  
 
 0.897
CG7834
Uncharacterized protein, isoform A; Electron transfer activity. It is involved in the biological process described with: oxidative phosphorylation.
 
    
 0.893
Cyp4d20
Probable cytochrome P450 4d20; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
 
  
 
 0.886
Cyp4c3
Cytochrome P450 4c3; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
 
  
 
 0.881
CG33672
GEO02273p1; Iron-sulfur cluster binding. It is involved in the biological process described with: cellular iron ion homeostasis; [2Fe-2S] cluster assembly.
    
 
 0.880
Cyp4d14
Probable cytochrome P450 4d14; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
 
  
 
 0.874
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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