Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Pus7Pseudouridine synthase activity; RNA binding. It is involved in the biological process described with: pseudouridine synthesis. (734 aa)    
Predicted Functional Partners:
Pus1
Pseudouridine synthase activity; RNA binding. It is involved in the biological process described with: tRNA pseudouridine synthesis; mRNA pseudouridine synthesis.
   
 
 0.992
Nsun2
tRNA (cytosine(34)-C(5))-methyltransferase; RNA methyltransferase that methylates tRNAs. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Required for short-term memory.
   
 
 0.975
CG3709
Putative tRNA pseudouridine synthase Pus10; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase Pus10 family.
   
  
 0.963
CG1234
Nucleolar complex protein 3 homolog; Chromatin binding.
   
   0.961
CG3045
GH14326p; Pseudouridine synthase activity; RNA binding. It is involved in the biological process described with: tRNA pseudouridine synthesis; mRNA pseudouridine synthesis.
   
 
 0.955
RluA-2
Pseudouridine synthase activity; RNA binding. It is involved in the biological process described with: defense response to Gram-negative bacterium; positive regulation of innate immune response; enzyme-directed rRNA pseudouridine synthesis.
   
 
 0.949
RluA-1
RluA pseudouridine synthase 1 (RluA-1) encodes a pseudouridine synthase, an enzyme catalyzing the formation of the most abundant nucleoside modification of RNA, pseudouridine.
   
 
 0.944
Nop60B
H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. Required for maintenance of the germline stem cell lineage during spermatogenesis; Belongs to the pseudouridine synthase TruB family.
   
  
 0.928
wuho
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis.
   
 
 0.924
NHP2
H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
  
 
 0.920
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.