Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sePyrimidodiazepine synthase; Mediates the conversion of 2-amino-4-oxo-6-pyruvoyl-5,6,7,8- tetrahydropteridine (6-PTP; also named 6-pyruvoyltetrahydropterin) to 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4- one (pyrimidodiazepine or PDA), a key intermediate in red eye pigment drosopterin biosynthesis. (243 aa)    
Predicted Functional Partners:
CG10365
Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
     
 0.924
Prx6005
Peroxiredoxin activity; peroxidase activity. It is involved in the biological process described with: cell redox homeostasis; oxidation-reduction process; hydrogen peroxide catabolic process.
   
 0.916
CG2540
Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
     
 0.914
PHGPx
PHGPx (PHGPx) encodes a peroxidase involved in intestinal stem cell homeostasis and the response to endoplasmic reticulum stress.
   
 0.913
CG15116
Peroxidase activity; glutathione peroxidase activity. It is involved in the biological process described with: oxidation-reduction process; multicellular organism reproduction; response to oxidative stress.
   
 0.913
CG4829
Uncharacterized protein, isoform B; Peptidyltransferase activity; glutathione hydrolase activity. It is involved in the biological process described with: glutathione catabolic process.
   
 
 0.909
Ggt-1
Gamma-glutamyl transpeptidase (Ggt-1) encodes an enzyme that transfers the gamma-glutamyl moiety from donors to substrates, e.g. transfer to water generates glutamate. The roles of the product of Ggt-1 include glutathione metabolism, reproduction and light avoidance.
   
 
 0.909
CG17636
Uncharacterized protein, isoform C; Peptidyltransferase activity; glutathione hydrolase activity. It is involved in the biological process described with: glutathione catabolic process.
   
 
 0.909
CG1492
RE13973p; Peptidyltransferase activity; glutathione hydrolase activity. It is involved in the biological process described with: glutathione catabolic process.
   
 
 0.909
CG12116
RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process.
     
 0.905
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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