Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ergic53Ergic53, isoform A; Mannose binding. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; endoplasmic reticulum organization; Golgi organization. (512 aa)    
Predicted Functional Partners:
CG17271
Uncharacterized protein, isoform A; Calcium ion binding. It is involved in the biological process described with: multicellular organism reproduction.
   
 
 0.992
Sec23
Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.
   
 
 0.966
Sec31
Secretory 31 (Sec31) encodes a protein involved in the innate immune response.
   
 
 0.939
Surf4
Surfeit locus protein 4 homolog; Belongs to the SURF4 family.
   
 
 0.935
NTPase
NTPase, isoform F; Uridine-diphosphatase activity; guanosine-diphosphatase activity; Belongs to the GDA1/CD39 NTPase family.
   
   0.923
CG12817
Uncharacterized protein; Calcium ion binding.
   
 
 0.897
CG9175
FI09914p; GTPase activator activity; Sar guanyl-nucleotide exchange factor activity; GTPase binding. It is involved in the biological process described with: cell morphogenesis; regulation of COPII vesicle coating; protein secretion.
   
 
 0.896
Sec13
Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...]
   
 
 0.867
Sar1
Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24.
   
 
 0.861
Tango1
Transport and Golgi organization protein 1; Required for protein secretion. May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier. At basal transitional ER sites in follicle epithelial cells, mediates the exit of basal membrane protein such as vkg, LanB1 and Trol, from the endoplasmic reticulum (ER) to basal Golgi clusters.
   
  
 0.850
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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