Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
GAPsecGTPase activating protein, SECIS-dependent read-through (GAPsec) encodes GTPase-activating protein involved in translational readthrough. (403 aa)    
Predicted Functional Partners:
Rab35
Rab35, isoform A; Rab35 (Rab35) encodes a protein that regulates proximal versus distal growth of seamless tubes in the terminal cells of the tracheal system.
   
 
 0.866
wkd
TBC1 domain family member whacked; Essential for ensuring the polarized growth of tracheal seamless tubes. During seamless tube morphogenesis, likely to act as a GTPase-activating protein (GAP) for Rab35 to regulate vesicle trafficking from the recycling endosomes to the lumenal apical membrane to ensure the polarized dynein motor complex-dependent growth of seamless tubes along the proximodistal axis in tracheal terminal cells. When the terminal branch lumen is growing, Rab35-GTP is active and likely directs the transport of apical membrane vesicles from the soma to the distal tip of [...]
      
 0.792
CG7742
GH15768p; GTPase activator activity. It is involved in the biological process described with: regulation of GTPase activity.
      
 0.767
Evi5
Ecotropic viral integration site 5 ortholog; Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge.
      
 0.749
TBC1d7
TBC1 domain family member 7; Rab GTPase binding; TSC1-TSC2 complex binding; GTPase activator activity. It is involved in the biological process described with: activation of GTPase activity; negative regulation of insulin secretion; regulation of GTPase activity; negative regulation of TOR signaling; glucose homeostasis.
      
 0.747
sky
GTPase-activating protein skywalker; GTPase-activating protein (GAP) for Rab35 which regulates synaptic vesicle (SV) protein recycling and turnover at the neuromuscular junction boutons and possibly ventral nerve cord via endosomal trafficking. Inhibits Rab35-mediated endosomal sorting which traffics old or dysfunctional SV proteins through a degradative endolysosomal route that involves the ESCRT pathway and the HOPS complex members dor, vps39 and rab7. This function is essential for preventing excessive degradation and turnover of vesicles from the readily releasable pool which leads [...]
      
 0.740
eEFSec
Eukaryotic translation elongation factor, selenocysteine-specific (eEFSec) encodes a protein involved in the incorporation of selenocysteine during protein translation.
   
 
 0.734
CG17883
RE60063p; GTPase activator activity; Rab GTPase binding. It is involved in the biological process described with: regulation of GTPase activity; endoplasmic reticulum to Golgi vesicle-mediated transport.
      
 0.733
Pex6
Peroxin 6, isoform D; ATP binding; ATPase activity. It is involved in the biological process described with: peroxisome organization; protein import into peroxisome matrix; protein targeting to peroxisome.
      
 0.723
TBC1D23
Uncharacterized protein; GTPase activator activity. It is involved in the biological process described with: positive regulation of intracellular transport; retrograde transport, endosome to Golgi; regulation of GTPase activity.
      
 0.680
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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