Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
gene fusions
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[Homology]
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CuldCUB and LDLa domain (Culd) encodes a photoreceptor-cell enriched transmembrane protein. It localizes to endocytic vesicles and is required for endocytic trafficking of the products of ninaE and trpl. (965 aa)    
Predicted Functional Partners:
ninaE
Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization.
   
 
 0.676
CG12071
Uncharacterized protein, isoform D; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of gene expression.
   
  
 0.651
CarT
Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
   
  
 0.633
CG9427
GH19763p; Oxidoreductase activity.
   
  
 0.602
CG6511
IP13783p; It is involved in the biological process described with: positive regulation of transcription, DNA-templated.
      
 0.599
CG8620
Uncharacterized protein, isoform B.
      
 0.598
CG12947
Uncharacterized protein.
   
  
 0.593
Tsp
Thrombospondin, isoform A; Thrombospondin (Tsp) is expressed in embryonic tendons and is regulated by sr. The product of Tsp serves as a ligand for the integrin subunit encoded by if and is required for muscle adhesion to tendons.
      
 0.592
trp
Transient receptor potential protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development. Bel [...]
   
  
 0.552
Arr2
Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception.
   
  
 0.535
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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