STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Coexpression
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[Homology]
Score
CuldCUB and LDLa domain (Culd) encodes a photoreceptor-cell enriched transmembrane protein. It localizes to endocytic vesicles and is required for endocytic trafficking of the products of ninaE and trpl. (965 aa)    
Predicted Functional Partners:
ninaE
Opsin Rh1; Neither inactivation nor afterpotential E (ninaE) encodes a protein that plays a major role in light detection and vision. It is the rhodopsin expressed in the largest class of photoreceptors in the adult retina. The stimulation by light of the product of ninaE induces G-protein signaling activation, the opening of the channels encoded by trp and trpl and photoreceptor cell membrane depolarization.
   
 
 0.624
CG9427
GH19763p; Oxidoreductase activity.
   
  
 0.608
Tsp
Thrombospondin, isoform A; Thrombospondin (Tsp) is expressed in embryonic tendons and is regulated by sr. The product of Tsp serves as a ligand for the integrin subunit encoded by if and is required for muscle adhesion to tendons.
      
 0.604
CG5027
LD24073p; Thiol oxidase activity. It is involved in the biological process described with: peptidyl-cysteine oxidation; cell redox homeostasis.
      
 0.601
Ttd14
TRPL translocation defect protein 14; GTP-binding protein which is required for the light-dependent internalization of the TRPL ion channel from the rhabdomere on the apical surface of photoreceptor cells to the cell body and for the recycling of TRPL back to the rhabdomere in the dark. Binds to 3- phosphoinositide (PtdIns(3)P) and phosphatic acid and so may interact with membranes, particularly the early endosome membrane where PtdIns(3)P is predominantly localized. Plays a role in preventing photoreceptor degeneration.
      
 0.600
Arr2
Phosrestin-1; Arrestin 2 (Arr2) encodes a protein involved in rhodopsin inactivation that contributes to photoreceptor maintenance and smell and sound perception.
   
  
 0.577
trp
Transient receptor potential protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development. Bel [...]
   
  
 0.562
Chc
Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles.
     
 0.553
trpl
Transient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins.
   
  
 0.541
CG43340
Uncharacterized protein, isoform M.
   
  
 0.539
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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