STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Srp9Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Srp9 together with Srp14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of Srp9 and Srp14 is required for SRP RNA binding (By similarity). (77 aa)    
Predicted Functional Partners:
Srp68
Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Srp68 binds the 7S RNA, Srp72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity).
   
 0.999
Srp19
Signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
   
 0.999
Srp72
Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family.
   
 0.999
Srp14
Signal recognition particle protein 14; Endoplasmic reticulum signal peptide binding; 7S RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; protein targeting to ER.
   
 0.999
Srp54k
Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.
   
 0.997
SrpRalpha
Signal recognition particle receptor subunit alpha homolog; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May have a role in axonogenesis.
   
 
 0.920
RpL23A
Ribosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis; Belongs to the universal ribosomal protein uL23 family.
    
 
 0.908
RpL31
60S ribosomal protein L31; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL31 family.
   
 
 0.892
RpL15
60S ribosomal protein L15; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL15 family.
   
 
 0.891
RpL36
60S ribosomal protein L36; Component of the large ribosomal subunit.
   
   0.887
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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