Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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exexExtra-extra (exex) encodes a homeodomain transcription factor that is expressed in and regulates the differentiation of motor neurons that project axons to ventral body wall muscles. Within the central nervous system, the product of exex negatively interacts with the products of Lim3 and eve to govern neuronal specification and differentiation. The roles of the product of exex include neuronal specification and differentiation. (525 aa)    
Predicted Functional Partners:
tup
Tailup, isoform A; Tailup (tup) encodes a transcription factor that regulates neuronal sub-type identity, including motor, serotonergic and dopaminergic neuron identity. It regulates germ band retraction, dorsal closure, muscle and heart development.
   
  
 0.804
Lim3
Lim3, isoform G; Lim3 (Lim3) encodes a transcription factor that regulates neuronal sub-type identity, including motor neuron identity.
   
 
 0.794
vvl
POU domain protein CF1A; Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system. Belongs to the POU transcription factor family. Class-3 subfamily.
   
  
 0.741
Fer1
48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N.
      
 0.684
Oli
Olig family, isoform A; Protein dimerization activity. It is involved in the biological process described with: motor neuron axon guidance; regulation of transcription, DNA-templated.
   
 
 0.620
kek2
Kekkon 2.
   
  
 0.610
CG4328
FI06571p; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; neuron differentiation.
   
  
 0.608
Fas2
Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.
   
  
 0.595
mid
Midline, isoform A; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription corepressor binding.
   
  
 0.588
MFS15
Major facilitator superfamily transporter 15, isoform A; Transmembrane transporter activity. It is involved in the biological process described with: anion transport; transmembrane transport.
   
  
 0.520
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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