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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mthl6Probable G-protein coupled receptor Mth-like 6; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; response to starvation; cell surface receptor signaling pathway; determination of adult lifespan. (480 aa)    
Predicted Functional Partners:
mthl14
Probable G-protein coupled receptor Mth-like 14; G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway.
      
 0.662
CG15115
Uncharacterized protein.
   
  
 0.659
Indy-2
Protein I'm not dead yet 2; Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage (By similarity). Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
      
 0.606
mthl5
Methuselah-like 5 (mthl5) encodes a G protein-coupled receptor involved in heart morphogenesis.
      
 0.603
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
   
 
 0.498
CG15556
FI21270p1; G protein-coupled receptor activity. It is involved in the biological process described with: cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway.
      
 0.489
CG11318
RE14222p; G protein-coupled receptor activity. It is involved in the biological process described with: cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway.
      
 0.449
Cdk5alpha
Cdk5 activator-like protein (Cdk5alpha) encodes the sole, essential stimulatory subunit for the kinase encoded by Cdk5. The Cdk5/Cdk5alpha complex is active in post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.
   
  
 0.441
SIFaR
SIFamide receptor (SIFaR) encodes a G-protein coupled peptide receptor involved in both the neuropeptide and the G-protein coupled receptor signaling pathways. It is required for sensory perception of pain, determination of lifespan and sexual behavior.
    
 
 0.434
ninaD
Neither inactivation nor afterpotential D (ninaD) encodes a scavenger receptor involved in carotenoid transport, light detection and rhodopsin biosynthesis; Belongs to the CD36 family.
   
  
 0.431
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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