STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG18417RE13502p; Zinc ion binding; metallocarboxypeptidase activity. It is involved in the biological process described with: proteolysis. (427 aa)    
Predicted Functional Partners:
sti
Non-specific serine/threonine protein kinase; Sticky (sti) encodes a member of the AGC family of kinases that functions to regulate both actin-myosin-mediated cytokinesis and epigenetic gene silencing.
      
 0.790
Jon74E
Jonah 74E; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
   
 
 0.581
CG18179
RE53819p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
   
 
 0.535
CG33128
LP12231p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family.
   
  
 0.527
CG17134
RE02351p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family.
   
  
 0.523
Bace
Beta-site APP-cleaving enzyme (Bace) encodes an aspartic protease that cleaves amyloid precursor proteins. It contributes to glial cell survival and enhances neuronal degeneration caused by expression of Appl. In humans, Bace, together with the gamma-secretase complex, generates the toxic Abeta peptide that accumulates in Alzheimer's disease; Belongs to the peptidase A1 family.
   
  
 0.515
CG5860
Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; cell death; protein catabolic process; Belongs to the peptidase A1 family.
   
  
 0.508
CG31661
MIP16848p; Aspartic-type endopeptidase activity. It is involved in the biological process described with: eggshell chorion assembly; cell death; protein catabolic process; proteolysis; Belongs to the peptidase A1 family.
      
 0.503
CG17283
Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: protein catabolic process; proteolysis; Belongs to the peptidase A1 family.
      
 0.503
CG5863
Peptidase A1 domain-containing protein; Aspartic-type endopeptidase activity. It is involved in the biological process described with: proteolysis; protein catabolic process; Belongs to the peptidase A1 family.
      
 0.503
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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