Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RhoGEF4Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of stress fiber assembly; positive regulation of Rho protein signal transduction. (647 aa)    
Predicted Functional Partners:
Klp61F
Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...]
   
    0.695
RhoGAP54D
Rho GTPase activating protein at 54D, isoform A; GTPase activator activity. It is involved in the biological process described with: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; imaginal disc-derived leg morphogenesis.
   
 
 0.668
Cdep
Chondrocyte-derived ezrin-like domain containing protein, isoform G; Rac guanyl-nucleotide exchange factor activity; cytoskeletal protein binding; Rho guanyl-nucleotide exchange factor activity; DNA binding. It is involved in the biological process described with: regulation of Rho protein signal transduction; Rac protein signal transduction.
      
 0.656
Ziz
Zizimin, isoform K; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: compound eye development; regulation of Rho protein signal transduction; Belongs to the DOCK family.
      
 0.652
cyst
Uncharacterized protein, isoform C; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: regulation of Rho protein signal transduction; positive regulation of Rho protein signal transduction.
    
 
 0.621
RhoGAP16F
Rho GTPase activating protein at 16F, isoform E; GTPase activator activity. It is involved in the biological process described with: positive regulation of GTPase activity; signal transduction; imaginal disc-derived leg morphogenesis; regulation of GTPase activity.
   
 
 0.612
RhoGAP15B
Rho GTPase activating protein at 15B, isoform C; Phosphatidylinositol-3,4,5-trisphosphate binding; GTPase activator activity. It is involved in the biological process described with: positive regulation of GTPase activity; signal transduction; regulation of GTPase activity; imaginal disc-derived leg morphogenesis.
   
  
 0.605
Zir
Zizimin-related (Zir) encodes a Rho guanine nucleotide exchange factor involved in the cellular immune response; Belongs to the DOCK family.
   
  
 0.595
CG30456
Uncharacterized protein, isoform B.
      
 0.586
RhoGAP19D
GTPase activator activity. It is involved in the biological process described with: Rho protein signal transduction; imaginal disc-derived leg morphogenesis; regulation of GTPase activity.
   
 
 0.563
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.