STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RhoGEF4Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of stress fiber assembly; positive regulation of Rho protein signal transduction. (647 aa)    
Predicted Functional Partners:
Klp61F
Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...]
   
    0.718
RhoGAP16F
Rho GTPase activating protein at 16F, isoform E; GTPase activator activity. It is involved in the biological process described with: positive regulation of GTPase activity; signal transduction; imaginal disc-derived leg morphogenesis; regulation of GTPase activity.
   
 
 0.662
cyst
Uncharacterized protein, isoform C; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: regulation of Rho protein signal transduction; positive regulation of Rho protein signal transduction.
    
 
 0.657
CG30456
Uncharacterized protein, isoform B.
      
 0.619
msb1l
LD32040p.
   
  
 0.558
Pura
Puratrophin-1-like, isoform A; Puratrophin-1-like (Pura) encodes a RhoGEF involved in leg morphogenesis, neuron morphogenesis, and locomotor rhythm regulation.
      
 0.544
TyrRS
tRNA binding; tyrosine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tyrosyl-tRNA aminoacylation.
   
  
 0.538
pav
Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.
   
    0.537
CG42674
Uncharacterized protein, isoform C; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of Rho protein signal transduction; imaginal disc-derived leg morphogenesis.
      
0.532
CG15611
Uncharacterized protein, isoform A; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: response to endoplasmic reticulum stress; positive regulation of Rho protein signal transduction.
      
 0.517
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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