STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG17744AT01876p. (238 aa)    
Predicted Functional Partners:
CG13476
GEO12094p1.
   
   0.741
lft
Protein limb expression 1 homolog; Component of the Fat (ft) signaling pathway that functions in normal development of various organs such as the wing and leg. In developing imaginal disks, involved in regulating both the protein levels and apical localization of ft and ds. Involved in establishing planar cell polarity (PCP) along the anterior-posterior axis of the wing (the early Fz signaling event), probably by acting upstream of ds and ft to regulate Fz activity.
    
   0.704
Dysb
Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses. In response to high synaptic activity at neuromuscular junctions, stabilizes Pldn protein levels and, together with Pldn, plays a role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes ; Belongs to the dysbindin family.
    
   0.615
CG14305
AT25266p; Protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: intracellular signal transduction; protein phosphorylation.
   
    0.579
CG6380
AT25465p; Protein phosphatase inhibitor activity. It is involved in the biological process described with: regulation of phosphoprotein phosphatase activity; regulation of signal transduction.
   
    0.579
CG15177
AT17667p; Calcium ion binding.
   
    0.564
Mst33A
Mst33A, isoform A.
   
    0.562
CG6629
AT18465p; Succinate dehydrogenase activity. It is involved in the biological process described with: tricarboxylic acid cycle; mitochondrial electron transport, succinate to ubiquinone.
   
    0.538
RpL10Aa
Ribosomal protein L10Aa (RpL10Aa) encodes a component of the large ribosomal subunit. It is likely a retrogene derived from RpL10Ab and, unlike RpL10Ab, the expression of RpL10Aa is low in most tissues/developmental stages but enriched in the adult testis.
   
    0.532
ProtA
Protamine A (ProtA) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines.
   
    0.530
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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