node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG18754 | CG8519 | FBpp0292250 | FBpp0076651 | Uncharacterized protein, isoform B; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | 0.496 |
CG18754 | y | FBpp0292250 | FBpp0070070 | Uncharacterized protein, isoform B; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. | Yellow (y) is the founding gene of the Yellow family. Lack of y function results in an abnormal male courtship behavior and a characteristic yellow color of the adult cuticle and larval mouthparts; Belongs to the major royal jelly protein family. | 0.438 |
CG34195 | CG8519 | FBpp0111303 | FBpp0076651 | Methyltransferase-like protein; tRNA (cytosine) methyltransferase activity. It is involved in the biological process described with: tRNA methylation; Belongs to the methyltransferase superfamily. METL family. | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | 0.538 |
CG8519 | CG18754 | FBpp0076651 | FBpp0292250 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Uncharacterized protein, isoform B; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. | 0.496 |
CG8519 | CG34195 | FBpp0076651 | FBpp0111303 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Methyltransferase-like protein; tRNA (cytosine) methyltransferase activity. It is involved in the biological process described with: tRNA methylation; Belongs to the methyltransferase superfamily. METL family. | 0.538 |
CG8519 | CanA1 | FBpp0076651 | FBpp0306613 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Serine/threonine-protein phosphatase 2B catalytic subunit 1; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily. | 0.476 |
CG8519 | Gdi | FBpp0076651 | FBpp0311558 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | 0.430 |
CG8519 | Lrrk | FBpp0076651 | FBpp0306703 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | 0.750 |
CG8519 | MED7 | FBpp0076651 | FBpp0081787 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] | 0.520 |
CG8519 | Mkp3 | FBpp0076651 | FBpp0303122 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Dual specificity protein phosphatase Mpk3; Negatively regulates the activity of members of the MAP kinase family in response to changes in the cellular environment. Has a specificity for the ERK family. Acts as negative regulator in a variety of developmental processes including cell differentiation and proliferation controlled by the Ras/ERK pathway. Suppresses the photoreceptor cell differentiation and wing vein formation. Required for proper oogenesis and early embryogenesis. Functions autonomously in a subset of photoreceptor progenitor cells in eye imaginal disks. Appears also to [...] | 0.471 |
CG8519 | Nf1 | FBpp0076651 | FBpp0084326 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Neurofibromin 1 (Nf1) encodes a protein that functions as a GTPase activating protein for the products of Ras85D and Ras64B in the larval and adult nervous system. Loss of Nf1 results in excess Ras-Raf-ERK signaling and to a non-cell-autonomous cAMP/PKA signaling defect. The product of Nf1 contributes to postembryonic growth, learning/memory, and circadian rhythm. | 0.443 |
CG8519 | Rep | FBpp0076651 | FBpp0085658 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity). | 0.430 |
CG8519 | y | FBpp0076651 | FBpp0070070 | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | Yellow (y) is the founding gene of the Yellow family. Lack of y function results in an abnormal male courtship behavior and a characteristic yellow color of the adult cuticle and larval mouthparts; Belongs to the major royal jelly protein family. | 0.629 |
CanA1 | CG8519 | FBpp0306613 | FBpp0076651 | Serine/threonine-protein phosphatase 2B catalytic subunit 1; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily. | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | 0.476 |
CanA1 | Lrrk | FBpp0306613 | FBpp0306703 | Serine/threonine-protein phosphatase 2B catalytic subunit 1; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily. | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | 0.743 |
Gdi | CG8519 | FBpp0311558 | FBpp0076651 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | 0.430 |
Gdi | Rep | FBpp0311558 | FBpp0085658 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity). | 0.533 |
Lrrk | CG8519 | FBpp0306703 | FBpp0076651 | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | 0.750 |
Lrrk | CanA1 | FBpp0306703 | FBpp0306613 | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | Serine/threonine-protein phosphatase 2B catalytic subunit 1; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily. | 0.743 |
MED7 | CG8519 | FBpp0081787 | FBpp0076651 | Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] | RE30129p; GTP binding; GTPase activity. It is involved in the biological process described with: signal transduction. | 0.520 |