node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG12116 | Ddc | FBpp0071183 | FBpp0080710 | RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | 0.444 |
CG12116 | Dhpr | FBpp0071183 | FBpp0076258 | RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process. | 0.974 |
CG12116 | Pcd | FBpp0071183 | FBpp0084824 | RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | 0.476 |
CG12116 | Sptr | FBpp0071183 | FBpp0071184 | RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | Sepiapterin reductase (Sptr) encodes a sepiapterin reductase involved in the biosynthesis of tetrahydrobiopterin. | 0.910 |
CG12116 | Trh | FBpp0071183 | FBpp0072534 | RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | Tryptophan hydroxylase (Trh) encodes an enzyme that functions as the first and rate-limiting step in the synthesis of serotonin. | 0.955 |
CG12116 | ple | FBpp0071183 | FBpp0311654 | RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | Pale (ple) encodes a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development. | 0.935 |
Ddc | CG12116 | FBpp0080710 | FBpp0071183 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | 0.444 |
Ddc | Got1 | FBpp0080710 | FBpp0086370 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Glutamate oxaloacetate transaminase 1 (Got1) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis. | 0.914 |
Ddc | Got2 | FBpp0080710 | FBpp0077537 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Aspartate aminotransferase; Glutamate oxaloacetate transaminase 2 (Got2) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis, which in turn regulates postsynaptic receptor field size. | 0.919 |
Ddc | Sptr | FBpp0080710 | FBpp0071184 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Sepiapterin reductase (Sptr) encodes a sepiapterin reductase involved in the biosynthesis of tetrahydrobiopterin. | 0.403 |
Ddc | Tdc2 | FBpp0080710 | FBpp0085475 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Tyrosine decarboxylase activity; carboxy-lyase activity; pyridoxal phosphate binding. It is involved in the biological process described with: oviposition; locomotor rhythm; behavioral response to cocaine; cellular amino acid metabolic process; locomotory behavior. | 0.907 |
Ddc | Trh | FBpp0080710 | FBpp0072534 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Tryptophan hydroxylase (Trh) encodes an enzyme that functions as the first and rate-limiting step in the synthesis of serotonin. | 0.990 |
Ddc | amd | FBpp0080710 | FBpp0080698 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | 3,4-dihydroxyphenylacetaldehyde synthase; Catalyzes both the decarboxylation and deamination of L-dopa to 3,4-dihydroxylphenylacetaldehyde (DHPAA). Probably responsible for the protein cross-linking during the development of flexible cuticles. Participates in catecholamine catabolism. | 0.906 |
Ddc | ple | FBpp0080710 | FBpp0311654 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | Pale (ple) encodes a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development. | 0.990 |
Dhpr | CG12116 | FBpp0076258 | FBpp0071183 | NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process. | RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | 0.974 |
Dhpr | Pcd | FBpp0076258 | FBpp0084824 | NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process. | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process. | 0.984 |
Dhpr | Sptr | FBpp0076258 | FBpp0071184 | NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process. | Sepiapterin reductase (Sptr) encodes a sepiapterin reductase involved in the biosynthesis of tetrahydrobiopterin. | 0.970 |
Dhpr | Trh | FBpp0076258 | FBpp0072534 | NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process. | Tryptophan hydroxylase (Trh) encodes an enzyme that functions as the first and rate-limiting step in the synthesis of serotonin. | 0.948 |
Dhpr | ple | FBpp0076258 | FBpp0311654 | NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process. | Pale (ple) encodes a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development. | 0.946 |
Got1 | Ddc | FBpp0086370 | FBpp0080710 | Glutamate oxaloacetate transaminase 1 (Got1) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis. | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. | 0.914 |