node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hs2st | Hs6st | FBpp0080826 | FBpp0307227 | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | 0.970 |
Hs2st | Hsepi | FBpp0080826 | FBpp0085478 | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | Heparan sulfate C5-epimerase (Hsepi) encodes a heparan sulfate modifying enzyme, which catalyzes the C5-epimerization of glucuronic acid, converting it to iduronic acid. Hsepi loss results in minor morphological defects and lifespan reduction. | 0.909 |
Hs2st | Sdc | FBpp0080826 | FBpp0309695 | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | Syndecan (Sdc) encodes a transmembrane heparan sulfate proteoglycan. It binds to the products of sli and robo1 to regulate axon guidance at the CNS midline, and it cooperates with the product of Lar to promote synapse growth at the larval neuromuscular junction. | 0.746 |
Hs2st | botv | FBpp0080826 | FBpp0085763 | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | Exostosin-3; Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens. | 0.604 |
Hs2st | dally | FBpp0080826 | FBpp0297069 | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | Division abnormally delayed (dally) encodes a core protein of heparan sulfate proteoglycans of the glypican family. It acts as a co-receptor for growth factors and morphogens, such as the products of dpp, wg, hh, upd1 and FGFs, affecting signaling and distribution of these ligands. The roles of the product of dally include wing development and germline stem cell maintenance. | 0.569 |
Hs2st | dlp | FBpp0080826 | FBpp0075431 | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | Dally-like, isoform A; Dally-like (dlp) encodes a glypican that regulates the signaling strength and range of the morphogens encoded by hh and wg; Belongs to the glypican family. | 0.743 |
Hs2st | sfl | FBpp0080826 | FBpp0076677 | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in diffusion of morphogen wingless (wg) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of wg morphogens. Required for wg signaling dur [...] | 0.775 |
Hs2st | sotv | FBpp0080826 | FBpp0099953 | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens. | 0.771 |
Hs2st | ttv | FBpp0080826 | FBpp0423167 | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Botv is the trigger of heparan sulfate chain initiation and polymerization takes place by a complex of ttv and sotv. Plays a central role in the diffusion of morphogens hedgehog (hh), wingless (wg) and decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis which are required for movement of hh, d [...] | 0.742 |
Hs6st | Hs2st | FBpp0307227 | FBpp0080826 | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | 0.970 |
Hs6st | Hsepi | FBpp0307227 | FBpp0085478 | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | Heparan sulfate C5-epimerase (Hsepi) encodes a heparan sulfate modifying enzyme, which catalyzes the C5-epimerization of glucuronic acid, converting it to iduronic acid. Hsepi loss results in minor morphological defects and lifespan reduction. | 0.962 |
Hs6st | Sdc | FBpp0307227 | FBpp0309695 | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | Syndecan (Sdc) encodes a transmembrane heparan sulfate proteoglycan. It binds to the products of sli and robo1 to regulate axon guidance at the CNS midline, and it cooperates with the product of Lar to promote synapse growth at the larval neuromuscular junction. | 0.787 |
Hs6st | botv | FBpp0307227 | FBpp0085763 | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | Exostosin-3; Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens. | 0.584 |
Hs6st | dally | FBpp0307227 | FBpp0297069 | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | Division abnormally delayed (dally) encodes a core protein of heparan sulfate proteoglycans of the glypican family. It acts as a co-receptor for growth factors and morphogens, such as the products of dpp, wg, hh, upd1 and FGFs, affecting signaling and distribution of these ligands. The roles of the product of dally include wing development and germline stem cell maintenance. | 0.732 |
Hs6st | dlp | FBpp0307227 | FBpp0075431 | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | Dally-like, isoform A; Dally-like (dlp) encodes a glypican that regulates the signaling strength and range of the morphogens encoded by hh and wg; Belongs to the glypican family. | 0.886 |
Hs6st | sfl | FBpp0307227 | FBpp0076677 | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in diffusion of morphogen wingless (wg) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of wg morphogens. Required for wg signaling dur [...] | 0.769 |
Hs6st | sotv | FBpp0307227 | FBpp0099953 | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens. | 0.550 |
Hs6st | ttv | FBpp0307227 | FBpp0423167 | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Botv is the trigger of heparan sulfate chain initiation and polymerization takes place by a complex of ttv and sotv. Plays a central role in the diffusion of morphogens hedgehog (hh), wingless (wg) and decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis which are required for movement of hh, d [...] | 0.728 |
Hsepi | Hs2st | FBpp0085478 | FBpp0080826 | Heparan sulfate C5-epimerase (Hsepi) encodes a heparan sulfate modifying enzyme, which catalyzes the C5-epimerization of glucuronic acid, converting it to iduronic acid. Hsepi loss results in minor morphological defects and lifespan reduction. | Heparan sulfate 2-O-sulfotransferase (Hs2st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to 2-O position of glucuronic or iduronic acid residues of heparan sulfate. Loss of Hs2st function eliminates 2-O sulfation, but increases 6-O sulfation performed by the product of Hs6st. Simultaneous elimination of Hs6st and Hs2st functions disrupts FGF, Wg and Dpp signaling pathways. | 0.909 |
Hsepi | Hs6st | FBpp0085478 | FBpp0307227 | Heparan sulfate C5-epimerase (Hsepi) encodes a heparan sulfate modifying enzyme, which catalyzes the C5-epimerization of glucuronic acid, converting it to iduronic acid. Hsepi loss results in minor morphological defects and lifespan reduction. | Heparan sulfate 6-O-sulfotransferase (Hs6st) encodes a heparan sulfate modifying enzyme, which transfers a sulfate group to the 6-O position of glucosamine residues of heparan sulfate. Loss of Hs6st eliminates 6-O sulfation, but increases 2-O sulfation performed by the product of Hs2st. Simultaneous elimination of Hs6st and Hs2st disrupts FGF, Wg and Dpp signaling pathways. | 0.962 |