STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Prdm13PR/SET domain 13; Chromatin binding; nucleic acid binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of gene expression. (465 aa)    
Predicted Functional Partners:
CG4968
Ubiquitin thioesterase otubain-like; Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Belongs to the peptidase C65 family.
      
 0.658
CG7747
LD20635p; Ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; peptidyl-prolyl cis-trans isomerase activity. It is involved in the biological process described with: protein peptidyl-prolyl isomerization; mRNA splicing, via spliceosome; protein folding; protein polyubiquitination.
    
 
 0.636
FBgn0264326
DNA polymerase epsilon catalytic subunit 1; Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication. Has a role in the G1-S transition and/or S-phase progression of the mitotic cycle and endocycle progression. Involved in DNA synthesis during DNA repair (By similarity). [...]
   
  
 0.500
Fer1
48 related 1 (Fer1) encodes a basic helix loop helix (bHLH) transcription factor. It is mainly expressed in mature neurons and maintains neuronal identity, likely downstream of the product of N.
   
 
 0.445
HGTX
GTX/Nkx6B-like homeodomain protein; HGTX (HGTX) encodes a homeodomain transcription factor that acts in parallel with the product of exex to promote the development and differentiation of motor neurons that innervate ventral body wall muscles. Its major roles include neuronal specification and differentiation.
      
 0.442
otp
Homeobox protein orthopedia; May be involved in the development of the central nervous system; Belongs to the paired homeobox family. Bicoid subfamily.
   
 
 0.433
dila
Centrosomal protein of 131 kDa; Cilium-specific protein with a role in cilium/flagellum formation. May be involved in transport of components into the growing cilium. In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme.
    
 
 0.429
CG14984
GEO10764p1.
   
 
 0.425
Ldsdh1
Lipid droplet subset dehydrogenase 1; Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 
 0.409
kkv
Krotzkopf verkehrt (kkv) encodes a membrane-inserted glycosyltransferase family 2 chitin synthase that uses GlcNAc to produce the polysaccharide chitin, which is extruded to the differentiating cuticle and tracheal system (tracheal cuticle, tube diameter regulation and gas filling).
   
  
 0.401
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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