Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG7386FI21277p1; DNA binding; zinc ion binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated. (662 aa)    
Predicted Functional Partners:
CG17802
RE19693p; DNA-binding transcription factor activity; zinc ion binding; transcription regulatory region sequence-specific DNA binding; DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
  
 
0.773
grau
Grauzone (grau) encodes a transcription factor with the Cdc20 activator of the Anaphase Promoting Complex (APC) encoded by cort as key target. Absence of grau function results in the cort phenotype of female sterility, meiosis II arrest, and egg activation defects.
  
 
 
0.746
wek
Zinc finger protein weckle; Acts as an adapter to assemble/stabilize a Toll/wek/Myd88/tube complex; required for efficient recruitment of Myd88 to Toll. Dispensable for innate immune response; plays a minimal role, if any, in the immune defense against Gram-positive bacteria and fungi. Involved in dorsoventral axis determination.
  
  
0.705
Neu2
Neuroectoderm-expressed 2, isoform A; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
  
 
  
0.670
CG17568
IP01252p; Zinc ion binding; nucleic acid binding; transcription corepressor activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II.
  
 
0.655
CG10321
Uncharacterized protein, isoform B; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; zinc ion binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II.
      
 0.653
CG31457
LD10183p; Protein phosphatase 1 binding; zinc ion binding.
      
 0.600
CG13506
FI23916p1; Axon guidance receptor activity. It is involved in the biological process described with: synapse organization; homophilic cell adhesion via plasma membrane adhesion molecules.
      
 0.598
CG17097
AB hydrolase-1 domain-containing protein; Lipase activity. It is involved in the biological process described with: multicellular organism reproduction; lipid metabolic process.
      
 0.580
CG31109
RE17222p; Zinc ion binding.
   
  
 0.509
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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