STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Sf3b6Splicing factor 3B subunit 6; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (Probable). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (By similarity). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the in [...] (121 aa)    
Predicted Functional Partners:
Sf3b3
Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). May also be involved in the assembly of the 'E' complex (By similarity). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing [...]
    
 0.999
Phf5a
PHD finger-like domain-containing protein 5A; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; Belongs to the PHF5 family.
   
 0.999
Sf3b5
Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as component of spliceosome. As part of the spliceosome complex, plays a role in the regulation of spermatogonial differentiation. When associated with the SAGA transcription regulatory histone acetylation (HAT) complex, might be involved in the transcriptional activation of a subset of SAGA-regulated genes ; Belongs to the SF3B5 family.
   
 0.999
Sf3b1
Splicing factor 3b subunit 1, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: spliceosomal complex assembly; mRNA splicing, via spliceosome.
   
 0.999
Spx
Spliceosomal protein on the X; RNA binding; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.997
Sf3b2
Splicing factor 3b subunit 2, isoform A; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
    
 0.997
Sf3a2
Splicing factor 3a subunit 2; RNA binding; zinc ion binding. It is involved in the biological process described with: positive regulation of gene expression; spliceosomal complex assembly; mRNA splicing, via spliceosome.
   
 0.995
snf
U1 small nuclear ribonucleoprotein A; Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). Plays a role in regulating sex-lethal splicing; Belongs to the RRM U1 A/B'' family.
   
0.981
SNRPG
Probable small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly. Plays role in pre-mRNA splicing as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity).
   
  0.980
Mfap1
Microfibrillar-associated protein 1; Required for pre-mRNA splicing.
   
   0.976
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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