STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PVRAPPVR adaptor protein (PVRAP) encodes a protein implicated in VEGF/PDGF signaling. It binds to the product of Pvr and is required for downstream activation of Target of Rapamycin Complex 1. (474 aa)    
Predicted Functional Partners:
DIP-theta
Dpr-interacting protein theta; It is involved in the biological process described with: synapse organization.
   
    0.511
Sr-CIII
Scavenger receptor class C, type III.
      
 0.491
Pvr
Receptor protein-tyrosine kinase; PDGF- and VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (encoded by Pvf1, Pvf2 or Pvf3). It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner.
    
 
 0.484
NimB5
Nimrod B5, isoform A; It is involved in the biological process described with: defense response to bacterium.
      
 0.469
Spn31A
Serpin 31A; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; Belongs to the serpin family.
      
 0.465
NimB4
Nimrod B4; It is involved in the biological process described with: defense response to bacterium.
      
 0.461
CG16756
GEO08277p1; Lysozyme activity. It is involved in the biological process described with: defense response to Gram-negative bacterium; Belongs to the glycosyl hydrolase 22 family.
      
 0.449
IM33
Immune induced molecule 33 (IM33) encodes a protein that belongs to a class of small secreted peptides released in the hemolymph upon systemic microbial infection.
      
 0.439
Spn42Dc
Serpin 42Dc, isoform A; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of proteolysis; negative regulation of endopeptidase activity; Belongs to the serpin family.
      
 0.433
Spn47C
Serpin 47C, isoform A; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: multicellular organism reproduction; negative regulation of endopeptidase activity; Belongs to the serpin family.
      
 0.432
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.