STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ets65ADNA-binding protein D-ETS-3; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; cell differentiation; regulation of transcription by RNA polymerase II; Belongs to the ETS family. (728 aa)    
Predicted Functional Partners:
Ets21C
DNA-binding protein D-ETS-6; Ets at 21C (Ets21C) encodes a stress-inducible transcription factor that binds specifically to purine-rich DNA motifs. It cooperates with transcription factors acting downstream of the MAP kinase pathways to fine tune gene expression in response to stress, such as infection or oncogene activation.
  
 
0.817
CG15696
RT01055p1; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
      
 0.632
CG31955
GEO11681p1.
      
 0.522
Sox102F
Sox102F, isoform B; Sox102F (Sox102F) encodes a transcription factor in the Sox gene family that regulates the Wnt signaling pathway. Its roles include heart development and cardiac function, and wing vein development and patterning.
      
 0.503
Atac3
Ada2a-containing complex component 3 (Atac3) encodes a protein involved in chromatin remodeling and histone acetylation.
   
 
 0.495
CG10654
Uncharacterized protein, isoform B; It is involved in the biological process described with: regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II.
      
 0.495
CG34377
Uncharacterized protein, isoform C.
      
 0.493
CG4328
FI06571p; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; neuron differentiation.
   
 
 0.474
Awh
LIM/homeobox protein Awh; Probable transcription factor. Required for the establishment of a subset of imaginal tissues: the abdominal histoblasts and the salivary gland imaginal rings.
   
 
 0.461
ChAT
Choline O-acetyltransferase 13 kDa chain; Choline acetyltransferase (ChAT) encodes a protein that catalyzes the biosynthesis of the neurotransmitter acetylcholine. It is considered to be a specific marker for cholinergic neurons.
   
  
 0.426
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.