STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SrasCAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins; Belongs to the peptidase U48 family. (302 aa)    
Predicted Functional Partners:
ste14
Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. It is involved in the biological process described with: C-terminal protein methylation.
   
 0.989
CG17565
Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
   
 0.988
Fnta
Protein farnesyltransferase activity; CAAX-protein geranylgeranyltransferase activity. It is involved in the biological process described with: positive regulation of Ras protein signal transduction; protein geranylgeranylation; protein farnesylation.
   
 
 0.970
ste24b
Ste24b prenyl protease type I (ste24b) encodes a protein that, along with the products of ste24a and ste24c, are paralogous (tandemly duplicated) type I prenyl proteases. The product of ste24b plays an essential role in the male germline; Belongs to the peptidase M48A family.
    
 
 0.946
ste24a
Prenyl protease type I (ste24a) encodes a protein that, along with the products of ste24b and ste24c, are paralogous (tandemly duplicated) type I prenyl proteases; Belongs to the peptidase M48A family.
    
 
 0.944
ste24c
Ste24c prenyl protease type I (ste24c) encodes a protein that, along with the products of ste24a and ste24b, are paralogous (tandemly duplicated) type I prenyl proteases. The product of ste24c plays an essential role in the male germline; Belongs to the peptidase M48A family.
    
 
 0.944
CG7573
LP11230p; Metalloendopeptidase activity. It is involved in the biological process described with: CAAX-box protein processing.
    
 
 0.832
scny
Ubiquitin carboxyl-terminal hydrolase 36; Hydrolase that deubiquitinates polyubiquitinated target proteins including imd. Required for preventing the constitutive activation of the imd/NF-kappa-B (Imd) signaling cascade under unchalleneged conditions. Deubiquitinates imd linked 'Lys-63' chains which leads its proteasomal degradation and consequently down-regulation of the Imd signaling cascade. Removal of the activating 'Lys-63'-linked chains is likely to enable their replacement with 'Lys- 48'-linked chains which act as 'tags' the for proteosomal degradation of imd. Required for maint [...]
   
 
 0.803
Ras85D
Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.
   
 0.787
CG10778
Alkyl transferase; Dehydrodolichyl diphosphate synthase activity; polyprenyltransferase activity. It is involved in the biological process described with: polyprenol biosynthetic process; Belongs to the UPP synthase family.
   
  
 0.743
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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