| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG30391 | Usp47 | FBpp0071547 | FBpp0076802 | Uncharacterized protein. | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | 0.665 |
| CG30393 | Usp47 | FBpp0071546 | FBpp0076802 | AT15826p. | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | 0.665 |
| Ufd4 | Usp47 | FBpp0079663 | FBpp0076802 | E3 ubiquitin-protein ligase Ufd4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | 0.658 |
| Ufd4 | ctrip | FBpp0079663 | FBpp0290652 | E3 ubiquitin-protein ligase Ufd4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. | Circadian trip (ctrip) encodes a HECT ubiquitin ligase that regulates the levels and circadian oscillations of the transcriptional activator encoded by Clk. It plays a role in the control of rest-activity rhythms. | 0.597 |
| Ufd4 | poe | FBpp0079663 | FBpp0079167 | E3 ubiquitin-protein ligase Ufd4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. | Protein purity of essence; Has a role in growth of the perineurial glial layer of the larval peripheral nerve. May have a role in male fertility and eye development or function. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. | 0.822 |
| Usp16-45 | Usp30 | FBpp0309404 | FBpp0070793 | Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination. | Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park). Belongs to the peptidase C19 family. | 0.572 |
| Usp16-45 | Usp39 | FBpp0309404 | FBpp0074414 | Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination. | Ubiquitin specific protease 39; Thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; spliceosomal complex assembly; mRNA splicing, via spliceosome. | 0.904 |
| Usp16-45 | Usp47 | FBpp0309404 | FBpp0076802 | Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination. | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | 0.854 |
| Usp30 | Usp16-45 | FBpp0070793 | FBpp0309404 | Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park). Belongs to the peptidase C19 family. | Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination. | 0.572 |
| Usp30 | Usp39 | FBpp0070793 | FBpp0074414 | Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park). Belongs to the peptidase C19 family. | Ubiquitin specific protease 39; Thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; spliceosomal complex assembly; mRNA splicing, via spliceosome. | 0.502 |
| Usp30 | Usp47 | FBpp0070793 | FBpp0076802 | Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park). Belongs to the peptidase C19 family. | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | 0.525 |
| Usp39 | Usp16-45 | FBpp0074414 | FBpp0309404 | Ubiquitin specific protease 39; Thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; spliceosomal complex assembly; mRNA splicing, via spliceosome. | Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination. | 0.904 |
| Usp39 | Usp30 | FBpp0074414 | FBpp0070793 | Ubiquitin specific protease 39; Thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; spliceosomal complex assembly; mRNA splicing, via spliceosome. | Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park). Belongs to the peptidase C19 family. | 0.502 |
| Usp39 | Usp47 | FBpp0074414 | FBpp0076802 | Ubiquitin specific protease 39; Thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; spliceosomal complex assembly; mRNA splicing, via spliceosome. | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | 0.523 |
| Usp47 | CG30391 | FBpp0076802 | FBpp0071547 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | Uncharacterized protein. | 0.665 |
| Usp47 | CG30393 | FBpp0076802 | FBpp0071546 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | AT15826p. | 0.665 |
| Usp47 | Ufd4 | FBpp0076802 | FBpp0079663 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | E3 ubiquitin-protein ligase Ufd4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK. | 0.658 |
| Usp47 | Usp16-45 | FBpp0076802 | FBpp0309404 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | Ubiquitinyl hydrolase 1; Zinc ion binding; thiol-dependent ubiquitin-specific protease activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein deubiquitination. | 0.854 |
| Usp47 | Usp30 | FBpp0076802 | FBpp0070793 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | Ubiquitin carboxyl-terminal hydrolase 30 homolog; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (park). Belongs to the peptidase C19 family. | 0.525 |
| Usp47 | Usp39 | FBpp0076802 | FBpp0074414 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways. Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway. Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev. Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putati [...] | Ubiquitin specific protease 39; Thiol-dependent ubiquitinyl hydrolase activity; zinc ion binding; thiol-dependent ubiquitin-specific protease activity. It is involved in the biological process described with: protein deubiquitination; spliceosomal complex assembly; mRNA splicing, via spliceosome. | 0.523 |