| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG3719 | Prx2540-2 | FBpp0070224 | FBpp0087354 | EG:132E8.3 protein; Disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis. | Peroxiredoxin 2540-2 (Prx2540-2) encodes a peroxidase involved in hydrogen peroxide catabolism. | 0.614 |
| CG3719 | Prx3 | FBpp0070224 | FBpp0082927 | EG:132E8.3 protein; Disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis. | Thioredoxin peroxidase 3; Peroxiredoxin 3 (Prx3) encodes an antioxidant protein involved in hydrogen peroxide catabolism and regulation of apoptosis. | 0.653 |
| CG3719 | Txl | FBpp0070224 | FBpp0076804 | EG:132E8.3 protein; Disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis. | Thioredoxin-like (Txl) encodes a protein predicted to be involved in the cell redox homeostasis. | 0.881 |
| CSN5 | Rpn10 | FBpp0082743 | FBpp0078024 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. | 0.873 |
| CSN5 | Rpn11 | FBpp0082743 | FBpp0078664 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. | 0.759 |
| CSN5 | Rpn5 | FBpp0082743 | FBpp0078278 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | Regulatory particle non-ATPase 5; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process. | 0.972 |
| CSN5 | Rpn7 | FBpp0082743 | FBpp0083687 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | 26S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. | 0.913 |
| CSN5 | Rpn9 | FBpp0082743 | FBpp0083860 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | 26S proteasome regulatory complex subunit p39A; Structural molecule activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; proteasome assembly; proteasome-mediated ubiquitin-dependent protein catabolic process. | 0.869 |
| CSN5 | Rpt5 | FBpp0082743 | FBpp0083843 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | Regulatory particle triple-A ATPase 5 (Rpt5) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus. | 0.585 |
| CSN5 | Txl | FBpp0082743 | FBpp0076804 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | Thioredoxin-like (Txl) encodes a protein predicted to be involved in the cell redox homeostasis. | 0.850 |
| Prx2540-2 | CG3719 | FBpp0087354 | FBpp0070224 | Peroxiredoxin 2540-2 (Prx2540-2) encodes a peroxidase involved in hydrogen peroxide catabolism. | EG:132E8.3 protein; Disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis. | 0.614 |
| Prx2540-2 | Prx3 | FBpp0087354 | FBpp0082927 | Peroxiredoxin 2540-2 (Prx2540-2) encodes a peroxidase involved in hydrogen peroxide catabolism. | Thioredoxin peroxidase 3; Peroxiredoxin 3 (Prx3) encodes an antioxidant protein involved in hydrogen peroxide catabolism and regulation of apoptosis. | 0.460 |
| Prx2540-2 | Txl | FBpp0087354 | FBpp0076804 | Peroxiredoxin 2540-2 (Prx2540-2) encodes a peroxidase involved in hydrogen peroxide catabolism. | Thioredoxin-like (Txl) encodes a protein predicted to be involved in the cell redox homeostasis. | 0.598 |
| Prx3 | CG3719 | FBpp0082927 | FBpp0070224 | Thioredoxin peroxidase 3; Peroxiredoxin 3 (Prx3) encodes an antioxidant protein involved in hydrogen peroxide catabolism and regulation of apoptosis. | EG:132E8.3 protein; Disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis. | 0.653 |
| Prx3 | Prx2540-2 | FBpp0082927 | FBpp0087354 | Thioredoxin peroxidase 3; Peroxiredoxin 3 (Prx3) encodes an antioxidant protein involved in hydrogen peroxide catabolism and regulation of apoptosis. | Peroxiredoxin 2540-2 (Prx2540-2) encodes a peroxidase involved in hydrogen peroxide catabolism. | 0.460 |
| Prx3 | Txl | FBpp0082927 | FBpp0076804 | Thioredoxin peroxidase 3; Peroxiredoxin 3 (Prx3) encodes an antioxidant protein involved in hydrogen peroxide catabolism and regulation of apoptosis. | Thioredoxin-like (Txl) encodes a protein predicted to be involved in the cell redox homeostasis. | 0.593 |
| Rpn10 | CSN5 | FBpp0078024 | FBpp0082743 | Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of [...] | 0.873 |
| Rpn10 | Rpn11 | FBpp0078024 | FBpp0078664 | Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). Belongs to the peptidase M67A family. PSMD14 subfamily. | 0.999 |
| Rpn10 | Rpn5 | FBpp0078024 | FBpp0078278 | Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. | Regulatory particle non-ATPase 5; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process. | 0.999 |
| Rpn10 | Rpn7 | FBpp0078024 | FBpp0083687 | Regulatory particle non-ATPase 10 (Rpn10) encodes one of the polyubiquitin receptor subunits of the 26S proteasome. It recognizes and binds the polyubiquitin moiety of proteins intended for proteasomal degradation or the ubiquitin-like domain of extraproteasomal ubiquitin receptors. | 26S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. | 0.999 |
STRING v12.5 is now available!
