STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
scnyUbiquitin carboxyl-terminal hydrolase 36; Hydrolase that deubiquitinates polyubiquitinated target proteins including imd. Required for preventing the constitutive activation of the imd/NF-kappa-B (Imd) signaling cascade under unchalleneged conditions. Deubiquitinates imd linked 'Lys-63' chains which leads its proteasomal degradation and consequently down-regulation of the Imd signaling cascade. Removal of the activating 'Lys-63'-linked chains is likely to enable their replacement with 'Lys- 48'-linked chains which act as 'tags' the for proteosomal degradation of imd. Required for maint [...] (1038 aa)    
Predicted Functional Partners:
CG14220
FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II.
    
 0.912
p53
P53 protein long form variant 1; P53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair.
     
  0.900
Sras
CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins; Belongs to the peptidase U48 family.
   
 
 0.803
imd
Protein immune deficiency; Essential for the imd/NF-kappa-B (Imd) humoral and epithelial immune response to Gram-negative bacteria. Functions as an adapter protein that transduces immunity signals from the activation of pathogen recognition receptors (PRRs) by bacterial infection to the Imd signaling pathway. Binding of diaminopimelic acid-type (DAP-type) bacterial peptidoglycans (PGN) causes multimerization or clustering of PGRP receptors which activate the Imd cascade probably by recruiting imd, Fadd and Dredd to the receptor complex. Once in proximity, Dredd cleaves imd in a Fadd-de [...]
    
 
 0.748
CYLD
Cylindromatosis, isoform D; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity, acting on linear ubiquitin.
      
 0.676
Usp5
Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 5 (Usp5) encodes an essential enzyme that cleaves unanchored lysine48-linked polyubiquitin chains. It is involved in photoreceptor differentiation, neuron pathfinding and apoptosis.
   
  
 0.673
trbd
Ubiquitin thioesterase trabid; Positive regulator of the Wnt signaling pathway. Specifically cleaves 'Lys-63'-linked ubiquitin chains. May act by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription (By similarity). Required for an efficient wg response, but not for other signaling responses, in the eye; Belongs to the peptidase C64 family.
      
 0.671
pirk
Poor Imd response upon knock-in (pirk) encodes a negative regulator of the immune deficiency (Imd) pathway, acting at the level of the product of PGRP-LC. Being regulated by the Imd pathway itself, it establishes a negative feedback loop adjusting Imd pathway activity to the severity of infection.
      
 0.652
Usp15-31
Ubiquitin specific protease 15/31 (Usp15-31) encodes a ubiquitin C-terminal hydrolase that is involved in the positive regulation of the apoptosome components encoded by Dark and Dronc; Belongs to the peptidase C19 family.
   
 
 0.646
POSH
Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway.
      
 0.627
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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