| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG7945 | DnaJ-1 | FBpp0075353 | FBpp0076830 | LD01461p; Chaperone binding; adenyl-nucleotide exchange factor activity. It is involved in the biological process described with: protein stabilization. | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | 0.952 |
| CG7945 | Hsc70-4 | FBpp0075353 | FBpp0082516 | LD01461p; Chaperone binding; adenyl-nucleotide exchange factor activity. It is involved in the biological process described with: protein stabilization. | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. | 0.890 |
| CG7945 | Hsc70Cb | FBpp0075353 | FBpp0292999 | LD01461p; Chaperone binding; adenyl-nucleotide exchange factor activity. It is involved in the biological process described with: protein stabilization. | Hsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. | 0.990 |
| CG7945 | Hsp68 | FBpp0075353 | FBpp0083974 | LD01461p; Chaperone binding; adenyl-nucleotide exchange factor activity. It is involved in the biological process described with: protein stabilization. | Heat shock protein 68 (Hsp68) encodes a protein involved in lifespan determination and response to heat shock and starvation. | 0.513 |
| CG7945 | Mlf | FBpp0075353 | FBpp0089346 | LD01461p; Chaperone binding; adenyl-nucleotide exchange factor activity. It is involved in the biological process described with: protein stabilization. | Myeloid leukemia factor; Transcription factor binding; chaperone binding. It is involved in the biological process described with: regulation of cell proliferation involved in compound eye morphogenesis; protein stabilization; regulation of transcription, DNA-templated; positive regulation of crystal cell differentiation. | 0.636 |
| CG7945 | mrj | FBpp0075353 | FBpp0297608 | LD01461p; Chaperone binding; adenyl-nucleotide exchange factor activity. It is involved in the biological process described with: protein stabilization. | Mrj, isoform E; Unfolded protein binding; chaperone binding. It is involved in the biological process described with: chaperone-mediated protein folding; chaperone cofactor-dependent protein refolding; protein folding. | 0.877 |
| DnaJ-1 | CG7945 | FBpp0076830 | FBpp0075353 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | LD01461p; Chaperone binding; adenyl-nucleotide exchange factor activity. It is involved in the biological process described with: protein stabilization. | 0.952 |
| DnaJ-1 | Hakai | FBpp0076830 | FBpp0303688 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase required during early development. E3 ubiquitin-protein ligases mediate ubiquitination of target proteins. Required for epithelial integrity and midgut morphogenesis. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. | 0.830 |
| DnaJ-1 | Hsc70-4 | FBpp0076830 | FBpp0082516 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. | 0.947 |
| DnaJ-1 | Hsc70Cb | FBpp0076830 | FBpp0292999 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Hsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. | 0.941 |
| DnaJ-1 | Hsf | FBpp0076830 | FBpp0110266 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | 0.924 |
| DnaJ-1 | Hsp68 | FBpp0076830 | FBpp0083974 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Heat shock protein 68 (Hsp68) encodes a protein involved in lifespan determination and response to heat shock and starvation. | 0.876 |
| DnaJ-1 | Hsp83 | FBpp0076830 | FBpp0305095 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.932 |
| DnaJ-1 | Mlf | FBpp0076830 | FBpp0089346 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Myeloid leukemia factor; Transcription factor binding; chaperone binding. It is involved in the biological process described with: regulation of cell proliferation involved in compound eye morphogenesis; protein stabilization; regulation of transcription, DNA-templated; positive regulation of crystal cell differentiation. | 0.950 |
| DnaJ-1 | mrj | FBpp0076830 | FBpp0297608 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Mrj, isoform E; Unfolded protein binding; chaperone binding. It is involved in the biological process described with: chaperone-mediated protein folding; chaperone cofactor-dependent protein refolding; protein folding. | 0.980 |
| DnaJ-1 | pirk | FBpp0076830 | FBpp0311731 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Poor Imd response upon knock-in (pirk) encodes a negative regulator of the immune deficiency (Imd) pathway, acting at the level of the product of PGRP-LC. Being regulated by the Imd pathway itself, it establishes a negative feedback loop adjusting Imd pathway activity to the severity of infection. | 0.904 |
| Hakai | DnaJ-1 | FBpp0303688 | FBpp0076830 | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase required during early development. E3 ubiquitin-protein ligases mediate ubiquitination of target proteins. Required for epithelial integrity and midgut morphogenesis. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | 0.830 |
| Hakai | mrj | FBpp0303688 | FBpp0297608 | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase required during early development. E3 ubiquitin-protein ligases mediate ubiquitination of target proteins. Required for epithelial integrity and midgut morphogenesis. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. | Mrj, isoform E; Unfolded protein binding; chaperone binding. It is involved in the biological process described with: chaperone-mediated protein folding; chaperone cofactor-dependent protein refolding; protein folding. | 0.641 |
| Hsc70-4 | CG7945 | FBpp0082516 | FBpp0075353 | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. | LD01461p; Chaperone binding; adenyl-nucleotide exchange factor activity. It is involved in the biological process described with: protein stabilization. | 0.890 |
| Hsc70-4 | DnaJ-1 | FBpp0082516 | FBpp0076830 | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | 0.947 |
