Shadow (sad) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 2 carbon of the cholesterol ring. sad mutants fail to undergo head involution, dorsal closure or to secrete cuticle.

Phantom (phm) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It is an endoplasmic reticulum protein that catalyzes the addition of a hydroxyl group to the 25 carbon of the cholesterol side chain. phm mutants fail to undergo head involution, dorsal closure and cuticle secretion.

Spookier (spok) encodes a cytochrome P450 involved in ecdysteroid biosynthesis that is expressed primarily in the prothoracic gland and is localized in the endoplasmic reticulum. Genetic evidence suggests that the product of spok acts with the products of sro and Cyp6t3 to catalyze conversion of 7 dehydrocholesterol to delta4, diketol during the ecdysone biosynthetic pathway.

Shroud (sro) encodes a short-chain dehydrogenase/reductase that is essential for ecdysone biosynthesis. It is hypothesized to work in the conversion of 7-dehydrocholesterol to 5beta-ketodiol; Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Halo (halo) encodes a protein that acts as cofactor of the molecular motor kinesin-1 and controls travel distances of moving lipid droplets. It determines the intracellular distribution of lipid droplets.

Disembodied (dib) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 22 carbon of the cholesterol side chain. dib mutants fail to undergo head involution, dorsal closure and to secrete cuticle.

Scavenger receptor class C, type II, isoform A; Polysaccharide binding; scavenger receptor activity. It is involved in the biological process described with: immune response.

Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis.

Cyp6d2 (Cyp6d2) encodes a member of the cytochrome P450 oxidase protein family and is involved in the detoxification of toxic compounds. Two common Cyp6d2 alleles found in many Dmel stocks result in extreme sensitivity to camptothecin.