STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AlaRS-mAlanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (1012 aa)    
Predicted Functional Partners:
TyrRS
tRNA binding; tyrosine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tyrosyl-tRNA aminoacylation.
  
 
 0.984
GluProRS
Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
  
 
 0.966
TyrRS-m
Tyrosine--tRNA ligase, mitochondrial; Tyrosyl-tRNA synthetase, mitochondrial (TyrRS-m) encodes an enzyme that catalyzes the ligation of tyrosine to the mitochondrial-encoded tRNA-Tyr. The TyrRS-m protein is encoded by a nuclear gene and imported to the mitochondria where it functions in mitochondrial protein synthesis; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.958
ProRS-m
Prolyl-tRNA synthetase, mitochondrial, isoform A; proline-tRNA ligase activity; ATP binding; glycine-tRNA ligase activity. It is involved in the biological process described with: glycyl-tRNA aminoacylation; prolyl-tRNA aminoacylation.
   
  
 0.955
HisRS
Histidyl-tRNA synthetase, isoform D; histidine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: histidyl-tRNA aminoacylation; mitochondrial translation.
  
 
 0.943
MetRS
Methionyl-tRNA synthetase (MetRS) encodes an enzyme that catalyzes the covalent attachment of methionine to methionyl-tRNA, an essential first step of protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.928
LysRS
Lysine--tRNA ligase; tRNA binding; ATP binding; lysine-tRNA ligase activity. It is involved in the biological process described with: lysyl-tRNA aminoacylation.
  
 
 0.923
AlaRS
Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 
 
0.913
ValRS
Valyl-tRNA synthetase, isoform C; aminoacyl-tRNA editing activity; ATP binding; valine-tRNA ligase activity. It is involved in the biological process described with: tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.911
GlyRS
Glycyl-tRNA synthetase, isoform B; Glycyl-tRNA synthetase (GlyRS) encodes a protein involved in dendrite morphogenesis and larval lymph gland hemopoiesis.
  
 
 0.906
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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