STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PrpkP53-related protein kinase (Prpk) encodes an atypical Ser/Thr kinase part of the KEOPS/EKC complex. It phosphorylates the product of p53 and is regulated by the products of Akt1 and Rab35. It is involved in tRNAs modification, telomere and chromatin dynamics. (224 aa)    
Predicted Functional Partners:
Tcs3
Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
 
 0.999
CG42498
GEO08993p1; It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; tRNA threonylcarbamoyladenosine metabolic process.
   
 0.992
CG14231
Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
  
 
 0.950
p53
P53 protein long form variant 1; P53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair.
   
 
 0.773
Rpp20
Ribonuclease P protein subunit p20; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity).
   
 
 0.695
CG33932
GEO12594p1; It is involved in the biological process described with: cellular calcium ion homeostasis.
   
 
 0.687
CG4338
Probable ribosome biogenesis protein CG4338; Probable pre-rRNA processing protein involved in ribosome biogenesis.
 
 
    0.684
CG14270
RE03721p; It is involved in the biological process described with: protein insertion into mitochondrial inner membrane.
   
  
 0.682
CG34117
GEO13368p1.
   
  
 0.676
CG33786
RE55868p; tRNA binding; nucleotidyltransferase activity; double-stranded RNA binding. It is involved in the biological process described with: regulation of translational fidelity.
   
  
 0.674
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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