STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cda4Chitin deacetylase-like 4; Chitin binding. It is involved in the biological process described with: chitin metabolic process; carbohydrate metabolic process. (486 aa)    
Predicted Functional Partners:
obst-B
BcDNA.GH02976; Chitin binding. It is involved in the biological process described with: chitin metabolic process.
  
  
 0.877
obst-A
Obstructor-A, isoform A; obstructor-A (obst-A) encodes a protein that forms a core complex with chitin and the chitin modifying proteins encoded by serp and knk. This complex is required for assembly, maturation and preservation of the chitinous cuticles at the end of embryogenesis and probably throughout larval development.
  
  
 0.875
serp
Serpentine, isoform B; Serpentine (serp) encodes a putative chitin deacetylase. It is expressed by the epidermal and tracheal cells and is secreted into the apical extracellular space. Its activity maintains the strength of cuticles and restricts tracheal tube length.
  
  
0.860
Gasp
Gasp, isoform A; Gasp (Gasp) encodes a protein involved in cuticle biosynthesis during embryonic tracheal system development.
   
  
 0.832
verm
Vermiform, isoform I; Vermiform (verm) encodes a chitin deacetylase-like protein that is secreted by tracheal cells and accumulates in the embryonic tracheal lumen. Its functions include cuticle development and tracheal tube size control.
  
  
0.831
Cht7
Chitinase 7 (Cht7) encodes an enzyme involved in cuticle development, ecdysis and wound healing; Belongs to the glycosyl hydrolase 18 family.
   
  
 0.810
kkv
Krotzkopf verkehrt (kkv) encodes a membrane-inserted glycosyltransferase family 2 chitin synthase that uses GlcNAc to produce the polysaccharide chitin, which is extruded to the differentiating cuticle and tracheal system (tracheal cuticle, tube diameter regulation and gas filling).
   
  
 0.787
CG3777
SD17974p.
   
  
 0.728
dsx-c73A
Doublesex cognate 73A (dsx-c73A) encodes a secreted cuticle protein present in the epidermis, salivary duct and trachea. The epidermal expression is under the control of the product of ovo.
   
  
 0.671
TwdlE
RE71854p; TweedleE (TwdlE) is one of 27 related insect-specific genes with a conserved domain, DUF243. TwdlE overexpression causes a Tubby-like phenotype similar to a mutant in the related TwdlD.
   
  
 0.651
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.