STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
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[Homology]
Score
ineSodium- and chloride-dependent GABA transporter ine; Plays a role in neuronal membrane excitation, important for normal response properties of the photoreceptor. Able to control excitability from either neurons or glia cells. Ine negatively regulates neuronal sodium channels. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve, ine and eag control perineurial glial growth through partially redundant pathways. Isoform A and isoform B are both functional, although isoform A functions with greater efficiency. Has a role in osm [...] (943 aa)    
Predicted Functional Partners:
CarT
Carcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
   
  
 0.890
CG4752
FI03324p; 5-oxoprolinase (ATP-hydrolyzing) activity. It is involved in the biological process described with: glutathione metabolic process.
   
  
 0.620
e
LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity.
      
 0.608
inc
Insomniac, isoform B; Insomniac (inc) encodes a BTB domain-containing protein that is essential in neurons for normal sleep-wake cycles.
      
 0.523
AGO1
Argonaute-1, isoform A; Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both.
   
   0.512
CG31663
GH27779p.
   
  
 0.512
Hdc
Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family.
  
  
 0.507
Balat
Beta-alanine transporter; Beta-alanine transporter required for the uptake of beta- alanine by the glia. Required for the recycling process of the neurotransmitter histamine in photoreceptor neurons of the compound eye and therefore for photoreceptor synaptic transmission. Following histamine release from photoreceptors and its uptake by glia, histamine is conjugated to beta-alanine by e/Ebony to form the inactive metabolite, carcinine.
   
  
 0.498
bnb
Protein bangles and beads; May play an important role during development.
   
  
 0.493
sgll
Sugarlethal, isoform A; Sugarlethal (sgll) encodes pyridoxine 5'-phosphate oxidase (PNPO). PNPO converts pyridoxine to its active form pyridoxal 5'-phosphate (PLP). PLP is a co-factor required for more than 100 enzymes that function in amino acid metabolism, gluconeogenesis and neurotransmitter synthesis.
      
 0.493
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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