| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG5316 | CG6171 | FBpp0083174 | FBpp0111839 | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. | 0.902 |
| CG5316 | DNAlig3 | FBpp0083174 | FBpp0082071 | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. | 0.832 |
| CG5316 | PNKP | FBpp0083174 | FBpp0081343 | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | FI07206p; Nucleoside monophosphate kinase activity; double-stranded DNA binding; polynucleotide 3'-phosphatase activity; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity. It is involved in the biological process described with: nucleotide phosphorylation; DNA repair. | 0.918 |
| CG5316 | Top1 | FBpp0083174 | FBpp0099689 | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex (By similarity). Introduces a single-strand break via transesterification at a target site in duplex DNA (By similarity). The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand (By similarity). The free DNA strand then undergoes passage around the unb [...] | 0.680 |
| CG5316 | XRCC1 | FBpp0083174 | FBpp0070730 | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | XRCC1 protein; Damaged DNA binding. It is involved in the biological process described with: base-excision repair; single strand break repair. | 0.994 |
| CG5316 | gkt | FBpp0083174 | FBpp0077263 | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] | 0.965 |
| CG6171 | CG5316 | FBpp0111839 | FBpp0083174 | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | 0.902 |
| CG6171 | DNAlig3 | FBpp0111839 | FBpp0082071 | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. | DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. | 0.979 |
| CG6171 | PNKP | FBpp0111839 | FBpp0081343 | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. | FI07206p; Nucleoside monophosphate kinase activity; double-stranded DNA binding; polynucleotide 3'-phosphatase activity; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity. It is involved in the biological process described with: nucleotide phosphorylation; DNA repair. | 0.905 |
| CG6171 | XRCC1 | FBpp0111839 | FBpp0070730 | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. | XRCC1 protein; Damaged DNA binding. It is involved in the biological process described with: base-excision repair; single strand break repair. | 0.986 |
| CG6171 | gkt | FBpp0111839 | FBpp0077263 | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] | 0.977 |
| CG6171 | mei-9 | FBpp0111839 | FBpp0070624 | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. | DNA repair endonuclease XPF; Implicated in recombination events during meiosis, mostly in meiotic exchange. May directly resolve Holliday junctions within recombination intermediates leading to DNA exchange. Also required for the repair of mismatches within meiotic heteroduplex DNA and for nucleotide excision repair. | 0.467 |
| DNAlig3 | CG5316 | FBpp0082071 | FBpp0083174 | DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | 0.832 |
| DNAlig3 | CG6171 | FBpp0082071 | FBpp0111839 | DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. | 0.979 |
| DNAlig3 | PNKP | FBpp0082071 | FBpp0081343 | DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. | FI07206p; Nucleoside monophosphate kinase activity; double-stranded DNA binding; polynucleotide 3'-phosphatase activity; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity. It is involved in the biological process described with: nucleotide phosphorylation; DNA repair. | 0.957 |
| DNAlig3 | Top1 | FBpp0082071 | FBpp0099689 | DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex (By similarity). Introduces a single-strand break via transesterification at a target site in duplex DNA (By similarity). The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand (By similarity). The free DNA strand then undergoes passage around the unb [...] | 0.471 |
| DNAlig3 | XRCC1 | FBpp0082071 | FBpp0070730 | DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. | XRCC1 protein; Damaged DNA binding. It is involved in the biological process described with: base-excision repair; single strand break repair. | 0.999 |
| DNAlig3 | gkt | FBpp0082071 | FBpp0077263 | DNA ligase 3 (DNAlig3) encodes an ATP-dependent DNA ligase that is involved in the repair of nuclear and mitochondrial single- and double-strand DNA breaks. | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] | 0.985 |
| PNKP | CG5316 | FBpp0081343 | FBpp0083174 | FI07206p; Nucleoside monophosphate kinase activity; double-stranded DNA binding; polynucleotide 3'-phosphatase activity; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity. It is involved in the biological process described with: nucleotide phosphorylation; DNA repair. | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity). | 0.918 |
| PNKP | CG6171 | FBpp0081343 | FBpp0111839 | FI07206p; Nucleoside monophosphate kinase activity; double-stranded DNA binding; polynucleotide 3'-phosphatase activity; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity. It is involved in the biological process described with: nucleotide phosphorylation; DNA repair. | Aprataxin and PNK-like factor; Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. | 0.905 |
