STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
betaggt-IIGeranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. Belongs to the protein prenyltransferase subunit beta family. (347 aa)    
Predicted Functional Partners:
CG12007
LD31216p; Rab geranylgeranyltransferase activity. It is involved in the biological process described with: protein geranylgeranylation.
    
 0.999
temp
Tempura, isoform A; Tempura (temp) encodes a protein-prenyltransferase subunit that regulates Notch signaling.
    
 0.998
Rep
Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity).
   
 0.993
PRL-1
PRL-1 phosphatase (PRL-1) encodes a growth inhibitor that counteracts the function of the product of the Src42A oncogene.
    
 0.914
Ykt6
YKT6 v-SNARE; Protein-cysteine S-palmitoyltransferase activity; SNAP receptor activity. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle-mediated transport; Belongs to the synaptobrevin family.
   
 
 0.871
Rab1
FI01544p; Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis.
    
 0.871
Rab11
Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions.
    
 0.832
CG9003
Uncharacterized protein, isoform B; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; response to endoplasmic reticulum stress.
    
 
 0.769
RabX2
CG2885; GTP binding; GTPase activity.
    
 0.759
Rab3
Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction.
    
 0.698
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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