Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
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[Homology]
Score
Ccdc85RE60986p; It is involved in the biological process described with: RNA interference. (607 aa)    
Predicted Functional Partners:
CG3558
UPF0518 protein CG3558.
   
  
 0.816
CG9083
Uncharacterized protein.
      
 0.813
ASPP
Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein (ASPP) encodes a scaffold protein localised at the adherens junctions (AJ) of epithelial cells. It promotes AJ stability by repressing Src activity via the kinase encoded by Csk.
   
 
 0.798
RhoGAP19D
GTPase activator activity. It is involved in the biological process described with: Rho protein signal transduction; imaginal disc-derived leg morphogenesis; regulation of GTPase activity.
    
 
 0.783
Sfp33A3
Seminal fluid protein 33A3; Enzyme inhibitor activity. It is involved in the biological process described with: negative regulation of catalytic activity; multicellular organism reproduction.
      
 0.741
Pp1alpha-96A
Serine/threonine-protein phosphatase alpha-1 isoform; Protein phosphatase 1alpha at 96A (Pp1alpha-96A) encodes a phosphatase involved in the regulation of Hedgehog and Wnt signaling pathways.
    
 
 0.721
CG3880
FI14130p.
    
   0.718
CG2006
FI21859p1.
      
 0.707
RASSF8
Ras association domain family member 8 (RASSF8) encodes a member of the N-terminal RASSF protein family. It localises with the product of ASPP at the adherens junctions of epithelial cells where it promotes junction stability by repressing Src activity via C-terminal Src kinase.
    
 
 0.697
CycK
Cyclin K (CycK) encodes a Cyclin-homologous subunit that forms a complex with the transcriptional kinase encoded by Cdk12. This complex phosphorylates the carboxy terminal domain of the large subunit of RNA polymerase II (encoded by RpII215) and contributes to pre-mRNA processing, transcription and chromatin structure.
      
 0.690
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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