Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG15399Uncharacterized protein; GTPase activity. (242 aa)    
Predicted Functional Partners:
RpII15
DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity); Belongs to the archaeal RpoM [...]
      
 0.824
roq
Roquin, isoform A; Ubiquitin protein ligase activity; RNA binding; metal ion binding; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination.
    
 
 0.816
CG12007
LD31216p; Rab geranylgeranyltransferase activity. It is involved in the biological process described with: protein geranylgeranylation.
      
 0.614
Ars2
Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha; Belongs to the ARS2 family.
      
 0.598
TfIIEalpha
Transcription factor IIEalpha (TfIIEalpha) encodes the large subunit of the RNA polymerase II general transcription factor TFIIE. The products of TfIIEalpha and TfIIEbeta are essential for transcription initiation in vitro acting with RNA polymerase II and the other general transcription factors.
   
  
 0.596
Rabex-5
Rabaptin-5-associated exchange factor for Rab5; DNA binding; zinc ion binding; Rab guanyl-nucleotide exchange factor activity.
    
 
 0.587
Als2
Alsin homolog; Has guanine nucleotide exchange factor (GEF) activity towards Rab5. Promotes the exchange of GDP to GTP, converting inactive GDP- bound Rab5 into its active GTP-bound form.
    
 
 0.587
Hsc70-1
Heat shock 70 kDa protein cognate 1.
  
 
 0.579
Hsc70-5
Heat shock 70 kDa protein cognate 5.
  
 
 0.557
Roe1
GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
  
 
 0.546
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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